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sh3pxd2a

Gene
SH3PXD2A
Protein
SH3 and PX domain-containing protein 2A
Organism
Homo sapiens
Length
1133 amino acids
Function
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Similarity
Belongs to the SH3PXD2 family.
Mass
125.289 kDa
Sequence
MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN

Gene
Sh3pxd2a
Protein
SH3 and PX domain-containing protein 2A
Organism
Mus musculus
Length
1124 amino acids
Function
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide (By similarity).
Similarity
Belongs to the SH3PXD2 family.
Mass
124.201 kDa
Sequence
MLAYCVQDATVVDVEKRRSPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADTNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKEAPAEGEGSEAPITKKEISLPILCNASNGSALAIPERTTSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEENPVGACESQGSPLKVKYEEPEYDVPAFGFDSEPEMNEEPSGDRGSGDKHPAQPRRISPASSLQRAHFKVGESSEDVALEEETIYENEGFRPYTEDTLSARGSSGDSDSPGSSSLSLAVKNSPKSDSPKSSSLLKLKAEKNAQAELGKNQSNISFSSSVTISTTCSSSSSSSSLSKNNGDLKPRSASDAGIRDTPKVGTKKDPDVKAGLASCARAKPSVRPKPVLNRAESQSQEKMDISSLRRQLRPTGQLRGGLKGSRSEDSELPPQMASEGSRRGSADIIPLTATTPPCVPKKEWEGQGATYVTCSAYQKVQDSEISFPEGAEVHVLEKAESGWWYVRFGELEGWAPSHYLVAEENQQPDTASKEGDTGKSSQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFGKTSGTVAVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDSLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSESPLLPTQRKGIPVSPVRPKPIEKSQFIHNNLKDVYISIADYEGDEETAGFQEGVSMEVLEKNPNGWWYCQILDEVKPFKGWVPSNYLEKKN

Gene
sh3pxd2a
Protein
SH3 and PX domain-containing protein 2A
Organism
Danio rerio
Length
1119 amino acids
Function
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation.
Similarity
Belongs to the SH3PXD2 family.
Mass
124.906 kDa
Sequence
MQFRTVLDVKVVDVEKRRNPSKHYVYLINVTYSDSTSHIIYRRYSKFFDLQMQILDKFPIEGGQKDPKKRIIPFLPGKILFRRSHVRDVAMKRLRFIDDYCRALVRLPPQISQSEEVLRFFETKPDDINPPVEDYGSKRKSGLDSSEPMVLEQYVVVANYERQENSEISLKAGETVDVIEKSESGWWFVSTAEEQGWVPATYLDSQSGTRDDLDLGTSRSGEVTKRRKAHLKRLDRRWTLGGIVNRQQSREEKYVSVQAYASQGKDEIGFEKGVTVEVIQKNLEGWWYIRYQGKEGWAPASYLKKLKDDLSPRKKTLTGPVEIIGNIMEISNLLNKKAVSEKDIQTDGEATTPERHISKSEISLPMPYAPEAGVAPTVVTALGMNSGSSATLQENKSRAEPGSPAIARVAPHRVEIGSPNLRQKPPPRRDANLAFQLPKPPEAPTVEAEYYTIAEFQSSISDGISFRGGQKADVIEKNSGGWWYVQIGDTEGWAPSSYIDKRKKPNLSRRTSTLTRPKVPPPAPPVKKQDSEEGPSLGGSASKAPESPQRVYEEPEYDVPALGFDSELDCNPPKPKTHNSPKPEPRKFEIKSNPAAAERIAQAGKASPLLKVMTSPLRKRNSLENINKEEVIYENEGFRFSSDDFASGCDSHTPRSLTLGRKPFGSSSGGGKPLRKVSPDLNRSHSLGRAERHSSKLFSDESARNPKREPVMRKDVEIRIGQSPLARPKPVVRPKPLLTKSEPQSPERMDISSIRRHLRPTGSLRQGAIRAMRGEDSETASVVSSEDSTSSRSTSDLSSVYSKGSRGGESDHESVLFRTTDAYERAQESELSFPAGVEVEVLEKQESGWWFVRWGSDEGWVPTFYLEPIKHTHNVGIQESRDSPLVDLGSTNKSNSLEKNEQRVQALNNLNQQNLRSMSNPSPPIPSKPPGGFSKPTAMLNGSSVRMRNGVRQAAVRPQSVFVSPPQPLKETNIHTGSLRRNESLGAGDHLRSTGGVRRNSSFTAVRPQPVTDVRVRAGTTITAPAGSSSPLIAQRNGIPISTVRPKPIEKMQLIHNNLREVYVSIADYRGDEETMGFSEGTSLEVLEKNPNGWWYCQVLDGLQGRKGWVPSNYLERKK