sgk-1

Serine/threonine-protein kinase sgk-1

464 amino acids

Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development. Does not appear to play a role in immune function.

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

54.252 kDa

MGSLYYSGSRMVRKDEVSCKLVMGDDKKTVVYAVRIGDGPIMQKVYEEYEKFFLTDVKDMVPEKFTIFPKKKLLQSKKTFFEKRRLWIQDVCQHLVDNQTKSEDVCRFFHIEAPDDDDNTVDLGPSERKTATANDFDFLTTIGKGSFGRVYQVRHKETKKIYAMKVLSKEHIRKKNEVKHVMAERNVLINNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFTESRSRFYAAEIACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKPYDKTVDWWCLGSVLYEMIFGLPPFYSKDHNEMYDKIINQPLRLKHTISVPCTELITGLLQKDRSKRLGHKNDFRDIQDHPFFLPVDWDKLLNRELKAPFIPKVKNAMDISNISKEFVEIQIDPASLAPQQLAVTHRDHDFENFTFVDTNRVLV

sgk-1

Serine/threonine-protein kinase sgk-1

463 amino acids

Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway (PubMed:15068796). Essential role in regulating development, stress response, and longevity (PubMed:15068796, PubMed:18782349). Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function (PubMed:18358814). Acts downstream of rict-1 to regulate fat storage, size, and development (PubMed:19240135, PubMed:19260765). Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development (PubMed:25383666). Does not appear to play a role in immune function (PubMed:18782349).

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

54.291 kDa

MGSMYYNESRMVRKDEVTCNVIIGDDKKTVVYALRIGNGPIMQKTFEEYERFFTTEKDMIPATIFTAPKKKFLQADSKFYEKRRVWILVISQHLVDNNLRSEDVRRFFHLESPDDDENNVDLGPSERKTATANDFDYLTTIGKGSFGRVYQVRHKETKKIYAMKILSKEHIRKKNEVKHVMAERNVLINNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYAAEIACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKPYDKTVDWWCLGSVLYEMIFGLPPFYSKDHNEMYDKIINQPLRLKHNISVPCSELITGLLQKDRSKRLGHRNDFRDIRDHPFFLPVDWDKLLNRELKAPFIPKVKNAMDTSNISKEFVEIQIDPSSLAPQQLAVTHRDHDFENFTFVDTNRVLV