Protein
O-methyltransferase SfmM3
Organism
Streptomyces lavendulae
Function
O-methyltransferase that mediates the methylation of 3-hydroxy-5-methyl-L-tyrosine (3-OH-5-Me-Tyr) into 3-hydroxy-5-methyl-O-methyltyrosine (3-OH-5-Me-OMe-Tyr), a core structure of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Sequence
MRRMLYAQLPSRALVVVAQLGIADILAEGPADISTLAERTSTDAVALARLLRGLAVFGVFEEGAEQVYSLTPLGEALTSGHPASALPSATLVAGQFGAAWGDLLETVRTGQSPFERSRGVSLFTHMEQDEELRAVFDDSQGRGLALELDEILRAIDFSAYPTVVDVGGSDGTFLRRILSAHPDISGIVFDLPGSTSLQAERPTADPLEGRYSVATGDFFDSLPEGGDLYLLSHILHDWDDDRAVQILRTCRAAMSDDATLMVVDLIAANRGQRDERLHTAALMDLYMLSLFGGNGGQERTAAQVEVLLSKAGFRITRVDSLPSGMNVIRAVRAA