sev

Protein sevenless

2594 amino acids

Receptor for an extracellular signal required to instruct a cell to differentiate into a R7 photoreceptor. The ligand for Sev is the Boss (Bride of Sevenless) protein.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

289.133 kDa

MFWREDAAQQQQQQQQQQQQQQQQQQPPHPPKRLSFSFNVKIAVNVNTKMSTTHINQERSKQQTTTGSRSRSRSNSNSSVSCKGDGDRRVRRHTTRLVGLRQQLLHLGRQLNPGQFLVTGHGGISTILIANLLLLLLLSLCCNVCCRSHIEPDQNLTPTTTSPAAVAVVPMLLPLAQTHMRPQLDSDVVEKVAVWTKHVGAAPPSIAEGIAISSVVRMPPSIQTPTETVRRQEQQRQQQQQQQEAAAAAAADAAIDERIVLERVTRDCVQRCIVEEDLFLDEFGIKCEKADNSDKCYKTRCNKGCAQWYRALKEIEPCQEACASTQFYPYDMPCIGACETAQRDYWHMQRLAMARLVETTQPQLLEMTDESSTLTIKWAMQFPENYLASRPFNIQYQQVDNQSEPEWHNLADYDCDEYYVCEILEALVPYTRYKFRFELPFGESSEDVLYSPATPVYETPMEGAPISAPIIVALLALDEHHVFVHWRPGRYSNAPIEGYRVLLTSAGNTSREQLLPAQRTSCIFAQLQPLTNYTVALTMINKQGEGPSTVVSIVTKSPLEPQQLQSVLLASEHSIIWQSLEPAGETRLLYTSEPAAISDFTFSQREQRLWLLDELGQLHSQLLDETTTSAARRLRLELPSNGSSQWTPRKLSLDWLQRRLYIAAQANSSDGAEGGFELFSSNLEGGDVQMAGVQLGLVVEQLELDALNGWLFWCDADSLWRLDLSSKQQLRLTQPAGAPGRFMLEPQRWLLHVLLPQENQLLELSYDGGHKHALALSNDSWRGFAWSSDQAQLLLANETQLQLLDGQTLVPLANWSPDGGCCALLPLERRRQPLSLEPPAPRELRALLGAQGAHITWQPPAANPYQTATAAARNFSYELEVLDVASQSAYNIRNIRVPHFGLERLQADNLYQLRVRANNAAGRAGVWTAPLATRTWPLGDHRLRWATQRGSLYTTNELGGQLQPLPVQLASSPGPLALVNASVAYYVSGREQSLHCVNLLQPQLSCTDERLEHVGAVAYDWRGGLLYWTDLARDCVQRLDPFSGERELLPIFGARHLALDSAQGHLYYSSSAHLARRSLSALSTHQPELEYYHVNGLAGQISGFCLDLPQRHIYWLVAGNSALHLYRTALSAGGSQAAVPLQLLTTLPAADALPHTLQHLAPLGALLWLAADGRGAHLLRLAAQLETDTDTMRLLPEGLVEPLSAVQLLERSAGPPPPPPDEGVRPLAVPPDSVHIDEGGHWNDFRVRWQPAASGGNHSVCYKLLLEHGSERLITLELLTPFARITQLAQAPLGLRISITPHTAWRAGSTTRVQLDTPVAAPTQPRRLRVFVERQAAPLQLAPNVSALLRWDVPEEHAGSQSLQYRISCWRGSELHSELLLNQSTLEARVEHLQPEETYRFQVQAHVAATGLAAGATSHALHVSPEVQSVPRLLYANAEHIGELDLDTGHRKQLVHTASPVEHLVVLQGEQRLLWVNEHVELLSHVPGKAPAKLARMRAEVLALTVDWVQRIVYWAELDAADGGCVIYSLDLCRFDGRILQGERLWSTPRGQLLRDLVALPHARQLVWLQHDLDSRNATLQGRSLANGSALTFEGVTLPLWRLFEGSQEPLAETLNLVDHLGRLCVYHVARQLCTSSALRAQLNLLNDDIGQLAQDPGYLYALRNGSVRAYGRRRQQLEFLLELQPDEVRLLRAYNYQAYPSRRCLLLPTTAAALESTPSSCEETQCSLQLPALSAAPDCPLPVPGLNYQLNLSSSSRSAQLELRSLHSAAGLTLNISQLQPYQAYELRAQVGSYYQQQLGQEPLQLPVLTLHTAAATPSAPRNFSGRALSPSELELSWLAPLELRSASVYYTLHWQLQLEDTEEQSQEQPAQEQRVETAGVQRLTGLQPARLYQVWLQAHATPSKYNSSGRLLIRSYAPLPPLQLIELNAYGMTLAWPGTPDALSSLTLECQSLREQLQFNVAGNHTQMRLAPLQPKTRYSCRLALAYAATPGAPIYFGPSHEYETLGDAPSAPGRPQLEHIAGEIFRVSWTPALDNGSPILLYNLEALQARRTNRRRRRRRETTLSLLPWAEEPLVIEDQWLDFCNTTELSCIVRELHTRRLLLFRVRARNRPHGWGPYSEDSERIAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKLQKRRHRAKKLLQQSRPSIWSNLSALQTQQQLLAARSRTFSMSLSDADIALLPQINWNRLTLLRFLGSGAFGEVYEGQLQAEDEAQPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLIGICCDTDSISLIMEHMEAGDLLSYLRAARPSSQEALSKLQLPELLSMCLDVANGCSYMEDMHFVHRDLACRNCLVSDGAAIGGRRIVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMALESLVDGLFSTQSDVWAFGVLCWEIFTLGQQPYAARNNFEVLAHVKEGGRLQQPERCPEKLYALLLQCWRSEPWERPSFKRCLSTLQALSSDLRRTEMLATDETPLVSALCAFKPDAKVRFDDAPQRLTLHLDAKDTVSTTDADTTGSPTTPTAPTTPTTTTSTIAVVSTAPSSENGQLYANEGISGL

sev

Protein sevenless

2554 amino acids

Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

287.025 kDa

MTMFWQQNVDHQSDEQDKQAKGAAPTKRLNISFNVKIAVNVNTKMTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGISTILIINLLLLILLSICCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWHKHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALKELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADGQSTPLTIRWAMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESGQMVSPAQQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESAQKVGESFDLPVEQLEVDALNGWIFWRNEESLWRQDLHGRMIHRLLRIRQPGWFLVQPQHFIIHLMLPQEGKFLEISYDGGFKHPLPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAASPSASWPLKNLPDCWAVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLRWASRQGSVIHTNELGEGLEVQQEQLERLPGPMTMVNESVGYYVTGDGLLHCINLVHSQWGCPISEPLQHVGSVTYDWRGGRVYWTDLARNCVVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDTQQDQLFWLVKGSGALRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLNLPMITASEDCPLPIPGVRYQLNLTLARGPGSEEHDHGVEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENLTLREVPLKDKQLYANEGVSRL