setdb1a

Histone-lysine N-methyltransferase SETDB1-A

1436 amino acids

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

160.025 kDa

MSREKDDENLLRMTKDDLQRWIQAEVERNPHLMQRREQLAQVEEWVKQKERDSTCTRLLYSNACESVLECESVMKGLYALLGLDYRDEDSEEEGGGGQPHDVIQIADDEAERRGNVICNGEDDDNDDLVVIDLGATKETLEPMLEKVTVAIQKSSKLVQDLVQMVSKTSMGATSPLSTSSSDINRPSSSSTPEIVRPESVTPKLEITNSITIVKTESLSSVPKISSLFNSSEQCKSIADHDSYFKPTIKTEPEWTPLTPWEDSESSPFEKLIKTESQSTDVTPSVMTPNKQPELLSFQSTTKIKPEPQSTQANTELSSPPSNSKLLENHNSLSIAAIKNESQLKASVSEVDLLESDSEQSDNAATKTRFKPSEVTASSKLKSSGDHNSASASLNRTDPKVRPVTPSGTPPPSKSPPAVDNTASVETNQTDSELPTETPVEESTLPSNPKEAVIMSDAESTDKTEKPQTRKKSSKPSVTTTSPESRLTSSKSPPVTKTSSTQKETARAQSPSDSIDESADMEDSPDEPSNSPTESPTKTPDKTTRNDAPAKPSKAKKSSKHSSSESSKTLKEIKLKVGAAVLGKKRHNHWSRGTVQEVETEDDGNTYKVEFKKGKTIVLSANHVAAYKPPSLKDLYIGCRVVASAKSENGKSLYNAGVMVELPERKNRMRFLVFFDDGLATYLALPDLYFVCKQTKKVWREIKDESSRKQVKDYLQVYPNPIAVVLRLGQETKAVRNGQFEDCTVLQLDGSLVQICYKNDKQKEWIYKGSDKLEHILTIKNRHKQHSHKKHHSPEGKTQSSQPKTLHSSKSASTSTSSANVSPVSSDSVSPARVTRQSDKTKTSISPQKIMSPAFQPKVVLQKISLPSSISPAARVSNSNTNSSLISAKRPAPDEEEDEYFSEDEVEVLEQEQNKSVYLHQRCCPACLEEVRPHQVDIHHGKNPLLIPLLFKFRRMTARRRIDGKLFFHIFYRSPCGRSLCDMQEVQDYLFETRCDFLFLEMFCMDPFVLVNRARPPSTTTGQPHLYLPDISEGKEVMPVPCVNEVDNTLAPNVTYTKDRVPARGVFINTSSDFMVGCDCTDGCRDRSKCACHKLTIEATSLCTGGPVDVSAGYTHKRLPTSLPTGVYECNPLCRCDPRMCSNRLVQHGMQLRLELFMTQHKGWGIRCKDDVPKGTFVCVFTGKIVNEDKMNEDDTMSGNEYLANLDFIEGVEKLKEGYESEAYCSDTEVESSKKTITMKTGPLLKNSLYKEDSSSGEEPMEVDTAKDKVKVHDKPLGERKLPNKPHETPKDTQKKISELRKNDGQESSGPKRCFAIKSFQRRVKPLESTEAQKEKTKTPKNTRGLFNDEDACYIIDARQEGNLGRYINHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYNYEVGSVEGKVLLCCCGSLRCTGRLL