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setd7

Gene
setd7
Protein
Histone-lysine N-methyltransferase SETD7
Organism
Halocynthia roretzi
Length
386 amino acids
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Mass
42.85 kDa
Sequence
MDSSDDEIACDEGDYKGAKDDNDLPHGLGKVKFSSGDEFIGAFEHGIKCGPGKFHFFDDSTLEGNYVDGELHGIGIYTNDDGSITKSTYCEGVMEGPSWEYDPEGNITFRGQYSEGVRCGLCFYYFPDGGSLIGNVNASGDLSADNIAYIYPDRTTALIGSFEEGDMITAKEANVTITGEKGEEISFPTVNSISPDPVYRLDVSTPHVISTRPLVPDPYESELVYAAPSKIPNAGEGLYAKCDVDQDTVMAFYNGVRLKQDEVENRDWSQNSNTISLTDDIAIDVPEEYVSTDNYCASLGHKVNHSFDPNCRYDIYQHPRFGFIKCVRTIRGVSEGDELTVHYTYEHNDGNKTREAEAPEWYKSQLKVFGVDRPAEILENMDEDYC

Gene
setd7
Protein
Histone-lysine N-methyltransferase SETD7
Organism
Danio rerio
Length
373 amino acids
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Mass
41.512 kDa
Sequence
MDSDDDNMEEVVEGPLDEDDQPHGFCTVTYSSSDRFEGHFVHGEKNGKGKFFFFDGSTLEGFYVDDALQGQGVYTYEDGGALHGFYVDGELNGPAQEFNSDGQLVFRGRYKDNIRYGMCWVYYPDGACVVGEVNEEGEMTGKAVAYVYPDGRTALYGSFVDGELIEARLATLTTQENGRPHFTVDPDSPIYCYDKSTSSCIAGHKLLPDPYESQRVYVGQSLISGAGEGLFAQTEAEANTVMAFYNGVRITHTEVDSRDWSMNGNTISLDEDTVIDVPAPFNMTENYCGSLGHKANHSFSPNCKYDQYVHPRFGQIKCIRTIRAVEKDEELTVAYGYDHEPSGKSGPEAPEWYTKQFLEFQQRESGKGADETC

Gene
SETD7
Protein
Histone-lysine N-methyltransferase SETD7
Organism
Homo sapiens
Length
366 amino acids
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Mass
40.721 kDa
Sequence
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK

Gene
Setd7
Protein
Histone-lysine N-methyltransferase SETD7
Organism
Mus musculus
Length
366 amino acids
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Mass
40.506 kDa
Sequence
MDSDDEVVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDSDGRLIFKGQYKDNNRHGVCWIHYPDGGSLVGEVNEDGEMTGEKIAYVYPDQRTALYGKFIDGEMLEGKLATLMATEEGRPHFEVTSGSSVYHFDKSTSSCISSDALLPDPYESERVYVADSLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCVYDLFVHPRFGPIKCIRTLRAVEAEEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK

Gene
setd7
Protein
Histone-lysine N-methyltransferase SETD7
Organism
Xenopus tropicalis
Length
366 amino acids
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Mass
40.816 kDa
Sequence
MDSEDETVEETVEGLLDDDGLPHGFCTVNYSSTDRFEGHFVHGEKNGRGKFYFFDGSTLEGFYVDDALQGQGIYTYEDGGSLHGTYVEGELNGPAQEYDTDGRLIFKGQYKDNVRHGVCWIYYPDGGSLVGEVNEDGDMTGDKVAYVYPDGRMALYGKFIDAEMLEGKLAILTSVDEGKPHFELVPNGPVYNFDKSTPSCISVNPLFPDPYESERVYVNDSLIHNAGEGLFAKVASAAQTVMSFYNGVRITHQEVDSREWALNGNTISLDDETVLDVPAPYNSYYKYCASLGHKANHSFSPNCMYDTFVHPRFGPIKCIRTMKAVEKDEELTVAYGYDHSVTGKNGPEAPEWYQQQLTAFQATQQK