setd6

Gene

Setd6

Protein

N-lysine methyltransferase SETD6

Organism

Rattus norvegicus

Length

474 amino acids

Function

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity).

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

53.362 kDa

Sequence

MAAPAKRARVSDASPLAAPCPVPRAAARVPLPLPAGPSGHEPESDAVAGFLRWCTRVGLELSPKVLVSRQGTVAGYGMVARESVQPGELLFAVPRSALLSPHTCSISDLLERERGALQSLSGWVPLLLALLHELQAPASPWSPYFALWPELGRLEHPMFWPEEERLRLLKGTGVPEAVEKDLVNIRSEYYSIVLPFMEAHSDLFSPTVRSLELYRQLVALVMAYSFQEPLEEEEDEKEPNSPLMVPAADILNHIANHNANLEYSAEYLRMVATQPILKGHEIFNTYGQMANWQLIHMYGFAEPYPNNTDDTADIQMVAVREAALQGTEDETERLLLCERWDFLCKQELVGEEGAFVIGREEVLTEEELATTLKVLCMPAEEFRDYKERAGWGEEETEDGSLAITNIPKLQESWKRLLRDSVLLTLQTYATDLKTEQDLLSNKEVYAKLSWREQQALQVRYGQKMILHRLLELTS

Protein

N-lysine methyltransferase SETD6: Setd6

Gene

SETD6

Protein

N-lysine methyltransferase SETD6

Organism

Homo sapiens

Length

473 amino acids

Function

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

53.189 kDa

Sequence

MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSPPAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS

Protein

N-lysine methyltransferase SETD6: SETD6

Gene

Setd6

Protein

N-lysine methyltransferase SETD6

Organism

Mus musculus

Length

473 amino acids

Function

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

52.96 kDa

Sequence

MAAPAKRARVSGGSPLVAPCPSPRAARAPLPLPAGSSGGEPEGDAVAGFLRWCRRVGLELSPKVTVSRQGTVAGYGMVARESVRAGELLFAVPRSALLSPHTCSISGLLERERGALQSLSGWVPLLLALLHELQAPASPWSPYFALWPELGRLEHPMFWPEEERLRLLKGTGVPEAVEKDLVNIRSEYYSIVLPFMEAHSDLFSPSVRSLELYQQLVALVMAYSFQEPLEEDDDEKEPNSPLMVPAADILNHIANHNANLEYSADYLRMVATQPILEGHEIFNTYGQMANWQLIHMYGFAEPYPNNTDDTADIQMVTVRDAALQGTKDETEKLLVCERWDFLCKQEMVGEEGAFVIGCEEVLTEEELATTLKVLCMPAEEFRDYKERAGWGEEETEDDSLAITDIPKLQESWKRLLRNSVLLTLQTYTTDLKTDQDLLSNKEAYATLSWREQQALQVRYGQKMILHRVLELTN

Protein

N-lysine methyltransferase SETD6: Setd6

Gene

setd6

Protein

N-lysine methyltransferase setd6

Organism

Danio rerio

Length

460 amino acids

Function

Protein-lysine N-methyltransferase.

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

53.007 kDa

Sequence

MATEAKRPKTGDEKSVLEPLNNFLLWCESVQLTLSDKVYLSKEGTAAEYGMLAKEDIEEGHVLFTIPREALLHQGTTKVKKVLEEGKKCLESASGWVPLLLSLMYEYTSSTSHWKPYLSLWPDFRTLDQPMFWSEEECDKLLKGTGIPESVITDLRKLQDEYNSVVLPFMKSHPDLWDPEKHNLELYKSLVAFVMAYSFQEPVEDDDEDEEDDEKKPNLPMMVPMADMLNHISKHNANLEYTPECLKMVSIRRIGKGEEVFNTYGQMANWQLLHMYGFAEPFPNNINETADIKMASVYKAAAQVARSEANQQLLEDKWKMLCEMEVVGEKGVFIFGQSGSLTYHELYTTLKVLCMSSQIFEDFRENEGWEEDDEDDDDKMEQDLSFEGLASLSVEWKRLLCVAATETLDSYNEDVETDRRLMEDQRALAELSSRERRALYVRLGQKNILQRIQQLTKPAS

Protein

N-lysine methyltransferase setd6: setd6

Gene

setd6

Protein

N-lysine methyltransferase setd6

Organism

Xenopus laevis

Length

455 amino acids

Function

Protein-lysine N-methyltransferase.

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

52.358 kDa

Sequence

MGPDAKKQKLEGVDHLQNGFPVTRFLAWCEKVGLELNPKVYISTEGTVSQYGMLAREDIADGELLFTVPRSAILSQNTTRIQELLEKEQESLQSTSGWVPLLISLLYEATDSSSLWAPYFGLWPELDPPDMPMFWSEEEQTKLLQGTGVLEAIRNDLKNIEEEYNSIVLPFITRNPEKFCPMKHTLDLYKRLVAFVMAYSFQEPLEENDEEDEDEKDILPPMMVPVADLLNHVAHHNAHLEFTPECLRMVTTKSVHAGQELFNTYGEMANWQLLHMYGFAEPHPQNSNETADIQMVTMREAALQAAQTEDDRLEMQKRWDFLCHIEMVGEEGAFVFGLEEVMTEEELKVSLKVLCMSKEEFAEYKENDGWEEDEGDDEQTLMIQEISHLPTPWRKLLHLSAKLTLKNYSTELSMDEALVNNITAYAKLSSREQRSLQVKYGQKRILHQLLELTKS

Protein

N-lysine methyltransferase setd6: setd6

Gene

setd6

Protein

N-lysine methyltransferase setd6

Organism

Xenopus tropicalis

Length

454 amino acids

Function

Protein-lysine N-methyltransferase.

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

52.331 kDa

Sequence

MGPDAKKQKLQSEDHLQNDLPVSCFLAWCKKVGLELNPKVYISTEGTVSQYGMLAREDLSDGELLFSIPRSAILSQNTTRIRDLIEKEQDSLQSCSGWVPLLISLLYEATDSSSHWAPYFGLWPELDPPDMPMFWSEEEQTKLLQGTGILEAVHKDLKNIEKEYNSIVLPFIRRNPEKFCPMKHTLDLYKRLVAFVMAYSFQEPQEEDEEEDIEKDILPPMMVPVADLLNHVAQHNAHLEFTPECLRMITTKSVCAGQELFNTYGQMANWQLLHMYGFAEPHPQNCNETADIQMVTVREAAFQVARTEEDRLEMQKRWDFLCHIEIVGEEGAFVFGLEEVMTEEELKACLKVLCMSTDEFAEYKENDGWEEDEDNDEQTLLTQEISRLPIPWRKLLHLSAELTLKAYKTELSMDEALVNDPTAYAKLSSREQHSLQVQYGQKKILHLLLELTKS

Protein

N-lysine methyltransferase setd6: setd6

Gene

SETD6

Protein

N-lysine methyltransferase SETD6

Organism

Bos taurus

Length

450 amino acids

Function

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

51.097 kDa

Sequence

MATQAKRRRVAGPAGSDDDPAPVASFLSWCQRVGLELSPKVAVSRQGTVAGYGMVARESVQPGELLFAVPRAALLSQHTCSISGVLERERGALQSQSGWVPLLLALLHEMQAPASPWSPYFALWPELGRLQHPMFWPEEERRRLLQGTGVPEAVEKDLVNIRSEYYSIVLPFMDAHPDLFSPRVRSLELYRQLVALVMAYSFQEPLEEEEDEKEPNSPLMVPAADILNHLANHNANLEYSPTCLRMVAIQPIPKGHEIFNTYGQMANWQLIHMYGFAEPYPDNTNDTADIQMVTVREAALQGTKVEAERLLLYERWDFLCKLEMVGEEGAFVIGREEVLTEEELATTLKVLCMPAEEFRAFKDQNGWEDDKSEEDSLTITDIPKLKASWRQLLRDSVLLTLQTYATDLKTEQDLLSNKEVYAALSWREQQALQVRYGQKMILHRLLELTR

Protein

N-lysine methyltransferase SETD6: SETD6

Gene

setd6

Protein

N-lysine methyltransferase setd6

Organism

Salmo salar

Length

449 amino acids

Function

Protein-lysine N-methyltransferase.

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

51.445 kDa

Sequence

MATDAKRLKTEGSDPLQSFLQWCEGVGLKLNNKVYISKEGTVAEYGMLAKEDIDEGELLFTIPRMALLHQGTTKVLAVLEEGKASLENTSGWVPLLLALMYEYTSPQSHWRPYLSLWSDFTALDHPMFWSKDERDRLLKGTGIPEAVDTDLTNIQKEYKDIVLPFITLHPDLWDPERHTLDLYRSLVAFVMAYSFQEPLDEEDEDEKDPNPPMMVPIADMLNHVSNHNANLEYTPECLKMVSVRSIRKGEEVFNTYGQMANWQLLHMYGLXEPYQSNSNDTADIPMSNVYKAAVQVTRSEAEQRLLVEKWSLLCEMEMVGDKGVFIFGKSGSLTDTEMYTTLKILCMSVEEFEDFRENEGWEEADDDEEKMLQALSNEGLPSLPPVWRCLVHAAARFTLDSYGEDMLKDKVLLEDKDGYAKLSSRQRRALQVRYGQKTILHQLLELTKP

Protein

N-lysine methyltransferase setd6: setd6

Gene

SETD6

Protein

N-lysine methyltransferase SETD6

Organism

Gallus gallus

Length

447 amino acids

Function

Protein-lysine N-methyltransferase.

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Mass

50.649 kDa

Sequence

MAAPAKRRRAAGPDPDPTAGFVAWCEAAGVELSPKVSISRRGTVSGYGLLAAADLEPGELLFSVPRSALLSQHTCAIRALLHDAQESLQSQSVWVPLLLALLHEYTTGTSRWRPYFSLWQDFSSLDHPMFWPEEERVRLLQGTGIPEAVDKDLANIQLEYSSIILPFMKSHPDIFDPELHTLELYKQLVAFVMAYSFQEPLEEEDEDEKGPNPPMMVPVADILNHVANHNASLEYAPTCLRMVTTQPISKGQEIFNTYGQMANWQLLHMYGFAEPYPGNTNDTADIQMVTVRKAALQRAKNEAQQQLVAEQWDFLCQLEMVGEEGAFVLGWDEVLTEEELSVTLKVLCMSEEEFKEYKEQDGWEDDSEEEENSTLSNAALSRLKAPCKALLYDSVLLTLESYRSDLRAEQDLLSKQVYEKLSRREQQALHVRYGQKRILHQLLELVQ

Protein

N-lysine methyltransferase SETD6: SETD6