Protein
Histone-lysine N-methyltransferase set9
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Histone methyltransferase that specifically methylates 'Lys-20' of histone H4. H4 'Lys-20' methylation is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
Sequence
MRQTNTHLETFSLFDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYIIEQTDLDQAAKNILQFRELDPLLRRLSSTSLLAFTRHLKYYLSLYLPSCKFEICSTNQYFSSSKPEACVIARESINAGEDITDLCGTIIKLSPKEERNIGIGKDFSILHSSRLDSMCLFLGPARFVNHDCNANCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERMGINGFKKLFHTSATSTSCSSKSSSDVSDLSSLPQSNRYVISEEDRSFLNIWDSGGELSDASSSDLDEEFSLFIPRHKKRVWSREKRLLSEMAITNHSPLLNVDDYRKFREDLWKKRHGKRKVYQCSNCSQTFINEDIQNSSAFCPKCIRHSKLFSLPWPCRHKVNRELKLEKEKEINTKRNLVTSSHSMSLRHKKAVDYQS