set-4

Gene

set-4

Protein

Histone-lysine N-methyltransferase Suv4-20

Organism

Caenorhabditis briggsae

Length

326 amino acids

Function

Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Mass

37.513 kDa

Sequence

MSHAPGEGRPVSSLFPARCNEEVASQNATTMATLNEIELSEIEELSLNFKETPRQDHSMTPVELCYFDDFATTLVVDAVLNFSTHKMCKKRRYLYGDEQRVARELMERFRKDQDWTPAIYGFLNMRSVRSFIEKLAFNKQLEFRDHIIRFLNVFHHDSGYTIQECTRYSLEGNQGAKLVATRAWYRGDKIQRLSGVVCLLSTQDEDTILQPEGSDFSVMYSNRKRCSTLWLGPGAYINHDCRPTCEFVSHGSTAHIRVLRDMVAGDEITCFYGSEFFGPKNMDCECLTCEKTKRGKFSTSDEEENDEPSALSEKRIKYGLRSRSRV

Protein

Histone-lysine N-methyltransferase Suv4-20: set-4

Gene

set-4

Protein

Histone-lysine N-methyltransferase Suv4-20

Organism

Caenorhabditis elegans

Length

288 amino acids

Function

Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3) (PubMed:22393255, PubMed:23028348). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes (PubMed:26641248, PubMed:23028348, PubMed:22393255). Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway (PubMed:23884442).

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Mass

33.189 kDa

Sequence

MQLHEQIANISVTFNDIPRSDHSMTPTELCYFDDFATTLVVDSVLNFTTHKMSKKRRYLYQDEYRTARTVMKTFREQRDWTNAIYGLLTLRSVSHFLSKLPPNKLFEFRDHIVRFLNMFILDSGYTIQECKRYSQEGHQGAKLVSTGVWSRGDKIERLSGVVCLLSSEDEDSILAQEGSDFSVMYSTRKRCSTLWLGPGAYINHDCRPTCEFVSHGSTAHIRVLRDMVPGDEITCFYGSEFFGPNNIDCECCTCEKNMNGAFSYLRGNENAEPIISEKKTKYELRSRS

Protein

Histone-lysine N-methyltransferase Suv4-20: set-4