Protein
CLIP domain-containing serine protease B14
Organism
Anopheles gambiae
Function
Serine protease (By similarity). Plays a role in innate immunity against infections by parasite P.berghei and by Gram-negative bacteria such as E.coli (PubMed:16188883). In response to P.berghei infection, contributes to the clearing of parasite ookinetes independent of melanization, an innate immune response which consists in the deposition of melanin pigments on invading pathogens and parasites (PubMed:16188883). May play a role in non-septic wound healing (PubMed:16188883).
Similarity
Belongs to the peptidase S1 family. CLIP subfamily.
Sequence
MYSRRYVACGLLCLLVIAIDQGHGQEHKPCTTPNGTAGRCVRVRECGYVLDLLRKDLFAHSDTVHLEGLQCGTRPDGGALVCCPAFVNEPNCGPSVFGVRIIGGNDTELGEFPWMALLRFQARNRKIHGNCGASLVSKRFVLSAAHCFTAAKSKGWKIHSVRVAEWNFMNHRGSKDCKQVKGYDVPICRKDYDVARFVQHPEYRVNAGVHVNDIVLIELAADVEYNVFVAPICLPVSNDTAQLPWGSSDDPEIEYTAAGWGSTESGKESTGMSYQLKQINLRAFNKERCKKLFQVPSGVGVGLGHICAGGIRDEDTCHGDSGGPLMEAVGGVWYLAGITSFGWPRCGRDGVPGVYTNISHYMGWLEREMFRGILA