sel-2

Putative neurobeachin homolog

2531 amino acids

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells (By similarity).

Belongs to the WD repeat neurobeachin family.

284.664 kDa

MDISETEYNDSDPPVQENGNGKAVVEDEVNDEESNMETVDLGLDDKTSDASSQNVFKNIDNEPSDDQQNVEESENITLEKPEEISAPPTVVSTSQDVSPPPAIESLPPLLEGKELELEDDVTSSLPRLLSKTTLIHSNEEGADETIQRLISSLHSNSPNMDRTQIVDHLFNLLVGGHFDQESKFVIEHVANVDHMLTLLSHCDCDLQNEIWSLFLAVMKKSNRNLEACTRVGLISKNFFLNLVLDLLPEAPPLLADLLVQIIAALVAYSINVKQTKHLLRALRSTKDQWPPNSLKLLHVLKEMPQHDSADVFFSFPGKDQSGIILPPIKTMPYQQGWTFATWLRMEPLNSVTFEKEQPVLYSFRTSKGIGYSCHIFGNCLVVNVEKAKGKEQSRCVKAELGARKWHHIAIAHCYSRWGRSDIKCFIDGQLAETIELSWVVTSTTSWDRCSIGVSADGAVNTAFCGQMGAMYLFAESLSLQQANSLFCLGPAYQSTFKHDSETSLPEGYKKHLFDGHLHSSLVFAYCPKNCHGQLCLFTPPKTAANTYFVQIPHAVMKEGVEVITTHSIHKSLQSVGGIQILLPLFAQIDLPSSHDNTIDGDVCQTLLSLISLLLSSSQSSQQQLFHSKGFLIISSCLQEASPSHLSMKVLEQIIHIAKFLLRCPAGGPLLKHLFDYILFNPKLWIRARPEVQVHLYQYLATDFLANNNFSQMLRRVPTVIEMCHTLKHFYWLALPQTVSDYTVEERPENFATAEIVSIRSAILTFINRIIISSNSPDEEEKARDQEIHTLLNLLATVREDDNLYDVLALVTRLLAEHPAIMIPAIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSRSTLKRKTESMGSQNLFSLIGERLLSHKRTISLPTYNVLLEVLVEQMTPTFTYAAHQPAQPDWKFENPHLLKVIAHVISQCEETESLVQIKKCFLIDIINLCRESKENRRTILQMSVWQDWLIGLAYVFHTSESQNEVSELVWEAFSILLHHALRHEYGGWRVWVDTLAIAHSKVSYEKFKRRLAEAKAKAEKAETGEEAKMEPTPVYRAPEFAWSEVHIRLLADLLSGIERTVEEWKTQEGGISDQCNASENQVFVGNVVHVISQLADSLIMACGGLLPLLASATAPNNDMEIVDPCQQQLPISVAASFLMRFAKLVDTFVLASGVSFSELEQEKNMPAGGVLRQSLRISATVTVRHILASRIQQPDTPRYETNSAKKNQCIMDFVKEALENFSPEGLENVERLVQDSDITRIKGVVYRDMVEENRQAQFLALSVIYLVSVLMVSRYRDILEPPSSPSPFFDSTTTKQENAERGEKLFEFSHNPLFLELPESSSEAVANGKVANDGDHASIKNGSDHSENGADEETEEKGEQGQGDNGGTIAAIKVANSDMKNDGNEYNEEELKKMHQSNGRRPSTLMPPQQTAERRAYLTTKLQTALETCAPLLREMMSDFRGYLQKTLVGTHGQEIMNDTKVLETLRNRNASVIELVMLLCSQEWQTSLQKHAGLAFIELVNEGRLMAHATRDHVLRVANEADFILNRLRAEDVSKHAQFEAESREQLNARYEEYSRCDLLIVSGRLRDSLNATRLLDKMSAILTDGDDSKSGSQFWKLDVWEDDSRRRKRFVPNPYGSRHEEANLPEGEKNEEPEISEQERIRKILKGLFSQRHATTTSTGGQELVDESDIDKWAQEVDPTPSSQSACFSTAAKLIVPGVVVPGTLSVTASDLFFDANESDPNYKKQCAQVLRYCEALHARWNLQEIRAIFLRRYLLQNTALEMFLASRTAIMFAFDSEDTVRKVVYQLPRVGVGVKYGLPQSRKTSLMTPRQLFKHSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVASNFRDLSKPIGALNEARRKFFTDRYASWDDDLVPAFHYGTHYSTPAFTLNWLLRLEPFASMFINLHDGKFDHPDRITHSIKDSWDRCQRDSHDVKELIPELFYLPEMFRNSSKFNLGRRADGTLVDDVVLPPWAESPEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNVFYHLTYEGTVTQKMAETPGQVSAIEQQILSFGQTPSQLLAEAHPPRHSIMTMAPTMFRRHDDDLCMMMKYISNSPVVYLAANTFHQLPHPTVVGVAQNLVFSLNKWDNSYSYGSTQRSALSMDPSNVEGQVALPLTADPQLATAASTTPIARRHLGDAFDQRLQVQCSNFVTTTDSKYIFACGYPDYSFRIVDTDSGRVRQAVYGHGDVVTCIARSETSLFSDCYVVTGSMDCTVVLWHWNGTTGFIAGEYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVILIHTTASDLLRRIRGHGTVTQLSMSRECILLVLFDSKRMTTYSSTARKLNEVLSEEKIECVTVTRDGEFAVTGAVNGRITIWRMFPLNKLYTYQPLNSAVRSVAVVASHRFILGGLDSGAIVVFNADFNRWHYEYKHRYIQNSSATKPAQASPQK

sel-2

Putative neurobeachin homolog

2507 amino acids

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells.

Belongs to the WD repeat neurobeachin family.

281.205 kDa

MEISETSHNESGPPVQENGIVEIPVEEGEEVNDEESNMETVDLGLDDSAADASSPSVFKNIDDEAPGDPSDAAKKEEDSEEIVVPSVLAPTPSQEVSPPNAIESLPPLPEGKELELEDDVTSSLPRLLSKTTLIHSNEEGADETIQRLVTVLHSNSPNTDRTQVVDNLFNLLVGGHFDQESKFVIEDAANVDHMLTLLSHCDYDLQNEIWSLFLAVMKKSNRNLEACTRVGLISKVLDILPEAPPLLADLLVQIIAALVAYSINVKQTKHLLRALKSTKEQWPPNSLKLLHVLKEMPQHDSADVFFSFPGKDQSGIILPPIKTMPYQQGWTFATWLRMEPLNSVTFEKEQPVLYSFRTSKGVGYSCHFTGNCLVVNVEKTKGKEQSRCVRAELGARKWHHIAIAHCYSRWGRSDIKCFIDGQLAETIELSWVVTSATNWDRCSIGVSADGTANSAFCGQMGAMYLFAEALTLQQANSLFCLGPVYQSTFKHDSETSLPEGYKKHLFDGHLHSSLVFAYCPKNCHGQLCLYTPPKTAASTYFVQIPHAVMKEGVEVITTHSIHKSLQSVGGIQILLPLFAQIDLPSSNDNSIDGEVCQTLLSLIALLLSSSQSSQQQLFHSKGFLIISSCLQKASPSHLSMKVLEQLIHIAKFLLRCPAGGPLLKHLFDYILFNPKLWIRARPEVQVHLYQYLATDFLANNNFSQMLRRVPTVIEMCHTLKHFYWLALPQTVSDYTIEERPENFATADIVAIRSSILTFINRIIIASAGPEEEERVRDQEVHTLLNLLATVREDDNLYDVLALVTRLLAEHPAIMIPAIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSRSTLKRKTESMGNQNLFSLIGERLLSHKKVLSLPTYNVLLEILVEQMTPTFTYACHQPAQPEWKFENPHLLKVIAHVISQCEESENIVQIKKCFLIDIINLCRESKENRRTILQMSVWQDWLIGLAYVFHTTESQNEVSELVWEAFSILLHHALRNEYGGWRVWVDTLAIAHSKVSFEKFKRKLAEAKIKAERSESGGEEAKMEPTPIYRAPEFAWSDVHVRLLADLLSGIERVVDEWKVAECGISDQCNASENQVFVGNVVHVVSQLSDSLIMACGGLLPLLASATAPNNDMEIVDPCQQQLPISVSAGFLMRFARLVDTFVLASGVSFSELEQEKNMPAGGVLRQSLRISATVTVRHILASRIQQPDTPRYETNSTKKNQCIMEFVREALEKRSPDGLENVERLVQDSDITRIKGVVYRDMVEENRQAQFLALSVIYLVSVLMVSRYRDILEPPSSPSPFFDSTTQKQENSENVNSETSPENGSNGKLANGGDNLSIKNGIESNGNDGEEEENGEEGQGDDGGRIAAIKVANADMKRGDGNEYDEEELSKMHQSNGRRPSTMMPVQQTAERRAYLTTKLQTALETCAPLLREMMSDFRGYLQKTLLGTHGQEIMNDTKVLETLRNRNASVIELVMLLCSQEWQTSLQKHAGLAFIELVNEGRLMAHATRDHVLRVANEADFILNRLRAEDVSKHAQFEAESREQLAARHEEYGRCDLLIASGRLRDSINATRLLEKMSAILSDQDDSKSGTQFWKLDVWEDDSRRRKRFVPNAYGSRHEEANLPEGEKNEEPEISEQEKIRKVLKGLFSKRQNSSGSHELVDESDIDKWAQEVDPTPSSQSACFSTTAKLIAPGVVVPGTLSVTANDLFFDANESDPNYKKQCAQVLRYCEALHARWNLQEIRAIFLRRYLLQNTALELFLASRTAIMFAFDSEDAVKKVVYQLPRVGVGVKYGLPQSRKTSLMTPRQLFKHSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVASNFRDLSKPIGALSEARRKFFNDRYTSWDDDQVPAFHYGTHYSTPAFTLNWLLRVEPFASMFINLHDGKFDHPDRITHSIKDSWDRCQRDSHDVKELIPELFYLPEMFRNSSKFNLGRRADGTPVDDVVLPPWAESPEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNVFYHLTYEGTVTPKMAETPGQVAAIEQQILSFGQTPSQLLTEAHPPRHSIMSMAPTMFRRHDEDLCMMMKYISNSPVVYLAANTFHQLPQPTVVGVAQNLVFSLNKWDNSYSYGASQRSALSMDPSNAEGQVSLPLTADAQLASAASTTPVARRHLGDAFDQRLTVQCSNFVTTTDSKFIFACGYPDYSFRIVDTDSGRVRQAVYGHGDVVTCIARSETSLFSDCYVVTGSMDCTVVLWHWNGTTGFIAGEYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVILIHTTSSDLLRRIRGHGIVTQLSMSRECILLSLFDSKRMVTYSATAKKLDEVLVDDKIECVTVTRDGEFAVTGAVNGRINIWRMFPLTKLYTYQPLNSAVRSVAVVASHRFILGGLDSGAIVVFNADFNRWHYEYKHRYIQNTSAAKPVQQSPQK