sel-10

F-box/WD repeat-containing protein sel-10

589 amino acids

Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determination by promoting female development. Potential regulator of presenilin. May have a role in egg laying. Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis. Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation.

65.816 kDa

MWPRNDVQMDEGSMTPEDQEPEPAIDQDMEFDVNLEENSYSNGSGSSYNADKLSSSSPLQHKLDLSASPTQNNEANPRVEHLVALFKDLTVAEQMEAFARLVQESNMSNIRQMRAIIEPHFQKDFLSCLPVEIGIKILQNLNSTDLMKVAQVSKNWKMLSEVEKVWKSLEDRGFKNLLEPSDRTRGAWEATAVIPGVNIPDHVNQCEINIHRLVKLLKYGPIYERSADKSRYLRGEKIEKNWHSRPIMGSAILRGHEEHVITCMQIHNDLLVTGSDDNTLKVWSIDDGEVKHTLNGHSGGVWTSQISQCGRYIVSGSTDRTVKVWRAEDGFLLHTLQGHTSTVRCMAMANTTLVTGSRDCTLRVWDIETGLHVRTLQGHQAAVRCVQFDGNIVVSGGYDFTVKIWDAFSGKCLRTLIGHSNRVYSLLYESERSIVCSGSLDTSIRVWDFSRPEGQELIAFLSGHTSLTSGMQLRGNILVSCNADSHVRVWDIYEGTCIHILSGHRSAITSLQWFGRGLVATSSDDGSVKLWDIERGVLIRDLVSLNSGGNGGCIWRLCSTQTMLACAIGSRNNTEETKVILLDFDANHP

sel-10

F-box/WD repeat-containing protein sel-10

587 amino acids

Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubMed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983).

65.312 kDa

MWPRNDVHMDDGSMTPEDQEPVTDNDMEYNDNGEESSYSNGSSSSYNADKLSSSRPLQHKLDLSASPSRNNDLNPRVEHLIALFKDLSSAEQMDAFTRLLQESNMTNIRQLRAIIEPHFQRDFLSCLPVELGMKILHNLTGYDLLKVAQVSKNWKLISEIDKIWKSLGVEEFKHHPDPTDRVTGAWQGTAIAAGVTIPDHIQPCDLNVHRFLKLQKFGDIFERAADKSRYLRADKIEKNWNANPIMGSAVLRGHEDHVITCMQIHDDVLVTGSDDNTLKVWCIDKGEVMYTLVGHTGGVWTSQISQCGRYIVSGSTDRTVKVWSTVDGSLLHTLQGHTSTVRCMAMAGSILVTGSRDTTLRVWDVESGRHLATLHGHHAAVRCVQFDGTTVVSGGYDFTVKIWNAHTGRCIRTLTGHNNRVYSLLFESERSIVCSGSLDTSIRVWDFTRPEGQECVALLQGHTSLTSGMQLRGNILVSCNADSHVRVWDIHEGTCVHMLSGHRSAITSLQWFGRNMVATSSDDGTVKLWDIERGALIRDLVTLDSGGNGGCIWRLCSTSTMLACAVGSRNNTEETKVILLDFDAVYP