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secBL

Gene
secBL
Protein
SecB-like chaperone MT2006
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
181 amino acids
Function
Chaperone component of an atypical, type II toxin-antitoxin chaperone (TAC) module, probably required for antitoxin HigA1 to neutralize its cognate toxin HigB1.
Similarity
Belongs to the SecB-like family.
Mass
20.105 kDa
Sequence
MTDRTDADDLDLQRVGARLAARAQIRDIRLLRTQAAVHRAPKPAQGLTYDLEFEPAVDADPATISAFVVRISCHLRIQNQAADNDVKEGDTKDETQDVATADFEFAALFDYHLQEGEDDPTEEELTAYAATTGRFALYPYIREYVYDLTGRLALPPLTLEILSRPMPVSPGAQWPATRGTP

Gene
secBL
Protein
SecB-like chaperone Rv1957
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
181 amino acids
Function
Chaperone component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Prevents antitoxin HigA1 aggregation in vitro at a 1:3 chaperone:antitoxin ratio, probably also protects antitoxin HigA1 from protease. Required for neutralization of toxin HigB1 upon ectopic expression in Mycobacterium marinum or E.coli. When expressed in E.coli complements a secB deletion, restores export of OmpA and MBP and inhibits aggregation of proOmpC although it is less efficient than endogenous SecB. Complements the general chaperone function of E.coli SecB less well.
Similarity
Belongs to the SecB-like family.
Mass
20.106 kDa
Sequence
MTDRTDADDLDLQRVGARLAARAQIRDIRLLRTQAAVHRAPKPAQGLTYDLEFEPAVDADPATISAFVVRISCHLRIQNQAADDDVKEGDTKDETQDVATADFEFAALFDYHLQEGEDDPTEEELTAYAATTGRFALYPYIREYVYDLTGRLALPPLTLEILSRPMPVSPGAQWPATRGTP

Gene
secBL
Protein
SecB-like chaperone SmegB
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
146 amino acids
Function
Chaperone component of an orphan antitoxin chaperone (AC) system; there is no toxin gene in close genomic proximity. When expressed in E.coli complements the cold-sensitive phenotype of a secB deletion, suggesting it may have a generic chaperone function. Does not however complement the toxin-neutralizing effect of its M.tuberculosis paralog Rv1957 (AC P95257) in E.coli, probably because the antitoxin genes are not from the same family.
Similarity
Belongs to the SecB-like family.
Mass
15.706 kDa
Sequence
MIERDGAPTFEDVQELLNRSELTDVALYEHAGRRVDDAVDDEFSLQVLTRVGDTEFEIRCKVTAAGHGGQYLADAGAVFTLQSAAKIEEGTAREFAEKVGVMAVYPYLRAAVSQSAASLGLDRPILPLLRAGGVKLTESMDSAEDA