About Products Protein Database Contact

sec66

Gene
SEC66
Protein
Translocation protein SEC66
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
206 amino acids
Function
Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC66 is required to attach or retain SEC72 in the SEC63 complex. It is essential for growth at elevated temperatures.
Similarity
To S.pombe SpBC409.21.
Mass
24.231 kDa
Sequence
MSEFNETKFSNNGTFFETEEPIVETKSISVYTPLIYVFILVVSLVMFASSYRKKQAKKISEQPSIFDENDAHDLYFQIKEMSENEKIHEKVLKAALLNRGAESVRRSLKLKELAPQINLLYKNGSIGEDYWKRFETEVKLIELEFKDTLQEAERLQPGWVQLFVMVCKEICFNQALSRRYQSILKRKEVCIKEWELKINNDGRLVN

Gene
sec66
Protein
Translocation protein sec66
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
192 amino acids
Function
Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec66 is required to attach or retain sec72 in the sec63 complex (By similarity).
Mass
22.136 kDa
Sequence
MVSIYVPLIYITILMGSMYGVSRFVRKSKNQESKPVSEEWFGENYSRNIFFSLLQQNPPAEDTLLKAALVLRATEGLRRLMKLKVSRMALNNLLNRGGVGDELIRKFGRLEKETELELMDIAKTANSLQPGWNQFIFQTCNEIIENEKIHSIIDNIPKDIDSISQRWQTEKILYEAADEELRIQAQKELGVL