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scc-1

Gene
scc-1
Protein
Sister chromatid cohesion protein 1
Organism
Caenorhabditis elegans
Length
645 amino acids
Function
Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle (PubMed:12827206, PubMed:12808038). The cohesin complex is required for the cohesion of sister chromatids after DNA replication (PubMed:12827206, PubMed:12808038). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).
Similarity
Belongs to the rad21 family.
Mass
73.409 kDa
Sequence
MFYAQFVLAKKGPLAKVWLAAHWEKKLTKAQIFETDVPQAIEEVIRPKVKMALRTVGHLLLGIVRIYSKKTRYLLADTNEAYQKMKINFRNGFSFEVDIPENAEIEEDFSNFIDKYNITVPEFHDADYNEQLIMANVSRREDITMKETVNFNVEFNIDADFDGFGDEGESWQLDHLYGSVEPLSLRPTPQPESLMEVERDRDVAANGTEISRIDADSVIFSEGPTRPNLIFDNQEGGNFMPEMNLKVENQTLENDGGVGPADMFSSMIHPVREHAVADVQNDDGMDFDYQPFEPENVEPSRPQSPESFALEPLDVEHMEGRKKRQRKARKLIVDAETMISNDAFREQQEDFSDTMRVVEMAPPTRKMFNLCVSGDLQHLSREPGCKMFNRELLQRYRRCLVTREFDLNYTMQELSDSSSFTPSMEAQAEPWEDLNLNEDIQEDIQAQGPAVDEFFNDVRMDDDDDRQPAQEMDFGDNFDFPQEVEHQECAPIPIQSGFAGENKENEDAEDWSDPFGSSNSSRRGQLEAYGFGNTSTYKEDDGKWAKRAKHILKKVSADIETSGQADFSSVTATAKNRKQAAEQFYSLLTLAKSQAISVDQSEPYGEIVIRPGANFKEACPLSSPKPMGLGNTMENSTMRTPMRPV