scaA

Sca1 complex scaffold protein scaA

1582 amino acids

Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:20493808). The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808). ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A (PubMed:20493808).

174.927 kDa

MSSLDPSLSTTPSTNRRGTFSKAKSFRRAALNLEPQGTPGQPHAFRFLSGEEYSGPDIIENIKKPININIESEEYKTPLFLGANGTLYNKYYIPIKIIGIDEPLPQTGLSPSLSSSSSSSSSPSPPTTTSTTPPPPNNNNNSKQIKKNNSISDLTPYLNFNSTDQIYTSFPESMAFDDYMDYEESLVEWKRQVEQNLGIIQLPHSIGRTYPRPKVIHEQLFRKNSEASNDDSISYDIERKLTDSDIKETNSSVNDDGESFSHSPTLRGNNGSSLSVGGGGDNHDNTSNKDNASSQGTNHGVTLNHPNSGINLRERSNSDTSTGSFEGTQLDGSSPMDGSPSTGSLAGFVANGTRSRTNSITYFDQRNQRSNSLSPKHSMLQSRLADSQSLDSSMYGKMGRSGSGFGMDHESWFLQKDPWDSQLILTEPHPDLFSTYEEYEYAMKNWAHEVITKTSILPPHPGQFIQLPKNSELSTDDGSGGGSGGSGVDGVGGNHQLGGSARHMLEMDFEMAKNQSNWTLRPIIRPIITEETMIFNRILSQSNLKHTEYDHLFSIDQELPPSQVWKTLDSDEKLKITETIDRWYRKKLTIQRQTSTWFRGGLWANHFLMPNIQSGWRESVSKKSSILPPLSLKALRRLDINSEADGKRVEHSFPIPELPINFNKLLAPDMNLQYFLGMLEMPTAHSLSSATGGQQQGGSGGGSGGSGSGSGSGSGLNMSGTSGSSGKSEKDKDKETANYIAMHSINNTTNVGTKEDRRQYTKILQTYEQRLQFSFRLDALNSWSEGGYTPMELQEKKLDIEQLVAAPGFDLQNGVWSLVNNSAHFLDKFQETFDQVDLRLYAPAIPMLPAIVPSVFINAGGGSGGGSGGASGGGISTSSGTSPNIVRPGSSSIGGGQPPSSPHIPSGSSLLSSPPNRQGSTGSFSFIGSPGGGGKISPTNSSSLESPRTQSQLAAVVERGSSPRSHSGGSISTHPNTPSVSSNTFLSLINTDSFPELLKFLDLTNEKLALGKISSLVLLVLTSELKGTMVIENILFSKDLQSLYRLARAISFFDAVPLDLFTYPTHLNEMLTPSIFKGSTQEVVRLVFVYYYLGIIQERLNFFSNNVGILGFVNSSRKDAAERIGIQFQNDREFLYKIFKALGRKSILVSNCFLFVLIQLIKMSESPTVQSLLKGELLTHIRDLSASKFSHSRFAAKRLYQILQEDPWKEFLMASYAESIKKNESQHLTDLTTMKEGPKLAIPSISLISELTFNFCVGVLENINSTPIPKPIYKFILNDSIFFQLCNAIVKCKNFTQSTQIVSKVFASLCKVLAKFNLFKNSDSIKSGGKVDPKKQNDVETGVAISPTLLFEIIGFLQNSSLDNNRYCSIIKTNMLIALRQLLKQSEIFDSIKKEGNLYNKFLIPACRDGKNVEFNRNVWRLFFQMIRFHHGHIEYLEKSKYLNALMDIISLNAGNVVLTNALHYLSKLFSLVSYETRKNALRAPGTLSIDTKYSEKDVKSLLNFFVERSCFIKFHMIYKKLTENTEGIQIDQRLLINITTFYRIISFLPSCQKLLKDTLKNPEYKTGIIQVSKMYKPSETF

scaA

Manganese ABC transporter substrate-binding lipoprotein

310 amino acids

Part of the high-affinity ABC transporter complex ScaABC involved in manganese import. Essential for growth under Mn(2+)-limiting conditions (PubMed:9440518). Also acts as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection (PubMed:7927711).

Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily.

34.788 kDa

MKKCRFLVLLLLAFVGLAACSSQKSSTDSSSSKLNVVATNSIIADITKNIAGDKINLHSIVPVGQDPHKYEPLPEDVKKTSKADLIFYNGINLETGGNAWFTKLVENAQKKENKDYYAVSEGVDVIYLEGQNEKGKEDPHAWLNLENGIIYAQNIAKRLIEKDPDNKATYEKNLKAYIEKLTALDKEAKEKFNNIPEEKKMIVTSEGCPKYFSKAYNVPSAYIWEINTEEEGTPDQIKSLVEKLRKTKVPSLFVESSVDDRPMKTVSKDTNIPIYAKIFTDSIAEKGEDGDSYYSMMKYNLDKISEGLAK