Protein
HTH-type transcriptional regulator SarT
Organism
Staphylococcus aureus (strain NCTC 8325)
Function
Transcriptional regulator acting as an intermediary between major regulators sarA and agr and virulence genes. Represses alpha-hemolysin (hla) gene expression. Down-regulates agr RNAIII expression by repressing sarU, a positive activator of agr expression. Up-regulates sarS, which induces the expression of the cell wall-associated protein A (spa).
Similarity
Belongs to the SarA family.
Sequence
MNDLKSKSNIKLMKRVLTTYELRKYLKKYFCLTLDNYLVLAYLDVFKNDEGKYFMRDIISYIGIDQSRIVKSVKDLSKKGYLNKCRDPHDSRNVIIVVSVKQHNYIKNLLSEININET