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sap30l-a

Gene
sap30l-a
Protein
Histone deacetylase complex subunit SAP30L-A
Organism
Xenopus laevis
Length
181 amino acids
Function
Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.
Similarity
Belongs to the SAP30 family.
Mass
20.903 kDa
Sequence
MNGFSTEEDSRDGPPAQAAPFFGQTCCLIDGGERCPRPAGNASFSKRVQKSISQKKLKLDIDKNVRHLYICDFHKNYIQSVRNKRKRKTSDDGGDSPEHETDIPEVDLFQLQVNTLRRYKRYYKLQTRPGLNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNRSRLDQKSESSKQLEA