sad-1

Serine/threonine kinase SAD-1

914 amino acids

Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology.

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

100.84 kDa

MFEALKEVLGEINSKLAAVNNELSSKIMSENIVSTRPVAQAQYCGPYKLEKTLGKGQTGLVKTGTHCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIEHPHVLHLYDVYENKKYLYLLLEHVSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICHRDLKPENLLLDERNNIKVADFGMASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRNLLEKVKRGVFHIPHFVPADVQSLLRAMIEVDPGKRYSLADVFKHPWVSGTTKADPELELPMSQVVQTHVIPGEDSIDPDVLRHMNCLGCFKDKQKLINELLSPKHNTEKMVYFLLLDRKRRRPAQEDDTEIVLRGAAQNNDPPKKRTDSSRTSRYPMGSIADGSPINPRKTYGRNQKSGRHSSLGGSPTESPRSSTRDLFGSSSSGSYSARAGEDRDRGRSASRSTNSYHYYTQPVDPQTLAEAARHVRDAQERRESRDSGRGSSRKESKDRSDKSASSSSCKNDASSTSSVPHKYSPPSVMSESVVVSSSTMNSTNSSTNSLIAGNSQTSIGSTSGPWRSKLNNIKNSFLGTPRFHRRKMSNGTAESDSEDSQMIDTTDLVKKSWFGSLASSMSVERDDTHCVPVQGKTLNSIKAELIRAFLQIHELSHSVVGQNCFRVEYKRGPTVGGSVFSRGIKMNVDIIPSPQQVVIAGETPTYVVQFVLLAGPVRRFKRLVEHLSAILQNSTQQRADRQQQAALMVRPRRLSDSSVGSACSDSESNASSINMIARHSDKTETTSATSSDPYGPSPSMRSVGSGTANSYKSPTPHRRNTTAVTASSSSASNRYGPSSSSSGSYSNNADYSYHPEYSQRSNGSSAPKNQYSPGSQRSFAFSMFNKADKV