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rtf2

Gene
Rtf2
Protein
Replication termination factor 2
Organism
Mus musculus
Length
307 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
33.935 kDa
Sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIRSIKNVTELRLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKKRMEERRLRAKLEKKTKKPKTATECASKPGTTQDSAGPSKVKSGKPEEADPDPREKKSTPAPRGAATNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF
Protein
Replication termination factor 2: Rtf2

Gene
RTF2
Protein
Replication termination factor 2
Organism
Gallus gallus
Length
306 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
34.222 kDa
Sequence
MGCDGGTIPKRHELVKGPRKAVKVDKTAELVARWYYCTLSQEKLCRPIVACELGRLYNKDAVIEFLLDKSADKTPMEAASHIKSLKNVTELNLADNPAWSGDKESKKGDTYDDIQSARFICPVVGLEMNGRHRFCFLRNCGCVFSERALKEIKTEVCHKCGVPFQEEDVIILNGNKEDVEVLKKRMEDRRLKSKLEKKSKKCKSAESAAQQVTTEDSPGPSKVKNSKDCIASSSGEKRHIIFTKSSDDRSSSVPGKVNKASTATKRSIADTATRNLRHTNLFTTHSSAKRPKEECSNWVTHTAYCF
Protein
Replication termination factor 2: RTF2

Gene
RTF2
Protein
Replication termination factor 2
Organism
Homo sapiens
Length
306 amino acids
Function
Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612).
Similarity
Belongs to the rtf2 family.
Mass
33.887 kDa
Sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIMLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
Protein
Replication termination factor 2: RTF2

Gene
RTF2
Protein
Replication termination factor 2
Organism
Macaca fascicularis
Length
306 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
33.87 kDa
Sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIVLNGTNEDVDVLKARMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEETSLDSREKKNNLAPKSAATNESFSGKAGKPLCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
Protein
Replication termination factor 2: RTF2

Gene
RTF2
Protein
Replication termination factor 2
Organism
Sus scrofa
Length
306 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
33.601 kDa
Sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSSEKALGKAASHIKSIKNVTELRLSDNPAWEGDKGSTKGDKHDDLQRARFICPVVGLEMNGRHRFCYLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIVLNGTKEDVAMLQTRMEERRLRAKLGKKTKKPKAAESVSKSDISEEAPGPSKMKAGKPEETSLDSREKKTSSAPRSAAAHGSSSGKAGKPVCGAPKRSIADSGESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
Protein
Replication termination factor 2: RTF2

Gene
RTF2
Protein
Replication termination factor 2
Organism
Pongo abelii
Length
306 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
33.825 kDa
Sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIVLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTATNESSSGKAGKPPCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
Protein
Replication termination factor 2: RTF2

Gene
Rtf2
Protein
Replication termination factor 2
Organism
Rattus norvegicus
Length
306 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
33.812 kDa
Sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEVLRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKATSHIRSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKRRMEERRLRAKLEKKTKKPKTAESASKLGISQDSAGPSKAKAGKSEEADPDPREKKSSLAPRGTASNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF
Protein
Replication termination factor 2: Rtf2

Gene
RTF2
Protein
Replication termination factor 2
Organism
Bos taurus
Length
299 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
33.149 kDa
Sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSSEKALGKAASHIKSIKNVTELRLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIVLNGTKEDVEVLKSRIEERRLRAKLGKKTKKPKVAESVSKSEVSEETPGPSKVKTGKPEETSLDTREKKTNSAPKSAAAHGITSGKAAKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
Protein
Replication termination factor 2: RTF2

Gene
rtf2
Protein
Replication termination factor 2
Organism
Dictyostelium discoideum
Length
273 amino acids
Function
Replication termination factor which is a component of the elongating replisome. Interacts with nascent DNA.
Similarity
Belongs to the rtf2 family.
Mass
30.71 kDa
Sequence
MGLDGGTIPTRCELVKTKKKEVKVFDKDQVDFGKWFLCALAQDTLSEPIVLDDLGNLFNKDNIIEALLNGSLETSKNFSHIRSLRSIYTVNFSPNPAHEKDSTVSPWLCPITKIEVGSSNYKFKFLKTCGHVFSEKAFKELKNDDSNNNNNNNNNNKKEIDSSKDNLSCFLCSKEYITNDLITINPSGEEFEQMKVTLQEKLANSKKKSSKKSDKKPDNKKRSLESNLASESSFTSNTLAQTNEEISKKMKSEAFSSIFKSNSNNDTTKTPNK
Protein
Replication termination factor 2: rtf2

Gene
rtf2
Protein
Replication termination factor 2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
240 amino acids
Function
Replication termination factor which mediates replication termination at the site-specific replication barrier RTS1. Stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin.
Similarity
Belongs to the rtf2 family.
Mass
27.057 kDa
Sequence
MGNDGGSLPTRNELVKEPGKVPPLDIDFKRSVKSSQFSQCAITDEPLYPPIVSCGLGKLYNKASILQMLLDRSSVPKSPSHIKSLKDVVQLQVELDDSGKVLWLCPITRHVMSDTYQFAYIVPCGHVFEYSALKQFGEKMCFQCNQVYEEKDVIPINPNAEQLKTLSKRLLDLALSEKTHSLNKASKKSNKNGDKKRKHVSKSNSKHAKHELRTNRMLDGENVKSETSVTDMERVKRVKI
Protein
Replication termination factor 2: rtf2