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rtel-1

Gene
rtel-1
Protein
Regulator of telomere elongation helicase 1 homolog
Organism
Caenorhabditis briggsae
Length
994 amino acids
Function
ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
Similarity
Belongs to the helicase family. RAD3/XPD subfamily.
Mass
112.715 kDa
Sequence
MVSNPSSSTEVWINSKTSIKFPFEPYECQRIFMKNVIDVLDMKLDAALESPTGTGKTLSLLCSTLAWVQKLKESKPMDFATWQSSGAGGAEKTEDKLKNSFIPTIFYASRTHSQLEQVVHELNRTEYKWVKTTILGSREHFCINQKVKKIKESNRQAHVCRGLVSKRSCHYYNKFDALTTDKANEILEKGEAMDIEDFVKIGTQNSICPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDLKNSIVIFDEAHNLESICESNASAELSSTSIALCIEELKKVLALLVEEEENAREEADNETEAFGTQKIDLTKKLIENLRTEDLMALLEKVFTLEENFDKLFESDQLKSVPPLDGKASDGAILLETLANSGCDGNSVERFVDVLRDAISYLLSKNEEVSLTEKGDGMESVADFLLSIYSTHAQEVAAAVGDEHIKLADRVDPATVARNCKLYIRKDSGKLVIKYFCFQASISMRMLKMRGVRNVLLASGTLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRGKHGGLVGSFQNRKNIEYVSDVGESLIRVMETTPQGVLVFFSSYSQMDELVEVWKKTKRGASDSPETFWEKMEKTKKIAVEPRAKEQLAAVRLRYTQGVSEPHGAALLAVCRGKVSEGIDFCDAESRAVIIVGIPYPPIHDERVVLKKMYLDDLMGRKDLTNEPQSSRDWYQMEAFRAVNQAIGRVLRHKNDFGTVVLIDTRYASAKPEMFPKWLRNTISRCDSNNCALKTARFFKERGHLIENSKSEYIKKQAKTCKSFRQVKSQSASNPKDDITDITLEDMFSPANMKIEKKEKIEPRPIKYDSSSSSVFSLPTNEDELKVKKWEQENDSQTNVSSSSDLNKRKYKAETPGNSSGQHVVSGSEPPKKRKMVLLTRETLPEKYQNALNIPTSELTKGMSLDNQKQFVATLKGYKATNMEWQEVFQRLHQIFIPDRPDLFISCSNILRSEDKMKYIRRSLGMKINY

Gene
rtel-1
Protein
Regulator of telomere elongation helicase 1 homolog
Organism
Caenorhabditis elegans
Length
994 amino acids
Function
ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
Similarity
Belongs to the helicase family. RAD3/XPD subfamily.
Mass
112.945 kDa
Sequence
MPPKASNSTEVWINPKLSVKFPFEPYECQRIFMKNVVDVLDRKLDAALESPTGTGKTLSLLCSTLAWVQRQKETKPLDFATWQTSGAGGAEKTDEKLKSAYVPTIFYASRTHSQLEQVVHELNRTEYKWVKTTILGSREHFCINQKVKKIKESNRQAHVCRGLVSKRACHYYNKFDACTTDKMTEFLDKGEAMDIEDFVKLGTQNSLCPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDLKNSIVIFDEAHNLESICESNASAELTSTSIALCIEELKKVLALLVDEEETARSEADAETGAFGSAKIDLTKKLIENLRTEDLMTVLEKIFSLEEEMDKLFGSSQLKSVPPLSGKASDGEILLETLAKAGFDANSVERLVDVLRDAISYLLSKNEEVALTEKGDGMEKVADFLLSIYSTHAQDVAAAVGEETVKLVDRVDPKTVARNCKLYIQKDKDNEKLTIKYFCFQASISMRMLKMRGVRNVLLASGTLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRGKRGGLAGSFQNRKNLDYVTGVAEALLRVMEVIPQGILIFFSSYSQMDELVATWKTTKWSSNSNESFWEKMEKTKRVVVEPRAKEELAAIRLRYTQGVSEQHGAALLAVCRGKVSEGIDFCDAESRAVIIIGIPYPPIHDERVVLKKMYLDDLMGRKDTKSERQSSQDWYQMEAFRAVNQAIGRVLRHKDDFGTVVLMDTRYASAKPEMFPKWLRNTISRSDTDGCALKTSRFFKERGHLIENSKTEYIKKQAKQCKSFRQVKQTAASDSKDDIIEITLEDMFSPANMKLEKKEITKLRPPQLIPSTSSVFSLPTNEDELKIKKWEQENDIQCLSSIPLESNKRKFKIETPGPSTSTLTQKSEPPKKKKILLLTRNTLPDEYQKAIEIPTSELLKDMSDDNKKQFATTLRSYKAESIRWDEVFQRFRPIFVPHKADLFIACSNVLRSEDKMKYLKKALESKIHT