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rtcA

Gene
rtca
Protein
Probable RNA 3'-terminal phosphate cyclase
Organism
Dictyostelium discoideum
Length
433 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
47.111 kDa
Sequence
MGKNKNYNKNQFKKSKTNNDTTVAQQQQTIEEKPDFKIDGSILEGGGQILRNSVALASLFNKAISIEKIRYNRDQPGLKNQHKAGIDLMSRLFKAHLTGCSVGSCKLYYQPTQKTIQDDGVIEADTKTAGSICLMIQVSLPCLIFAPHSTKMVLGGGTNCDFAPAADYIQNVFLPIATTMGFKCEMSIDKRGFYPKGGGAVTLTTQPLTQPLSPITIVNKGEVNRIVIKSYFTSPRISPLVAERMNNTAKKLIKKDFKKVDVETELIDVSKFSFGDGTFIEIRAYTDQGCIFGATGNGAIGVPAEKVAEDAANSLLKDLQDGGCMDEYLQDQLIIFMALAKGKSQIKTGPISLHTQTSIHITSLMTGAIFTITPLTNNTQSGEETNLITCEGISYFPSDLNNNNNNSNSNTTTTTTTTTISTTTIDNQNSEEK

Gene
RTCA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pongo abelii
Length
366 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
39.14 kDa
Sequence
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSKLHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFVFNCDIKTRGYYPKGGGEVIVRMSPVKQLDPVNLTDRGCVTKIYGRAFVTGVLPFKVAKDMAAAAARCIRKEIRDSYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIGAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKGTYIIECQGIGMTNPNL

Gene
RTCA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Bos taurus
Length
366 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
39.252 kDa
Sequence
MAGPRVEVDGGIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGVHTADTKTAGSVCLLMQVSMPCVLFAACPSELRLKGGTNAEMAPQIDYTAMVFKPIVEKFGFTFNCDIKMRGYYPKGGGEVIVRMSPVKQLSPINLTDRGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGAVDEYLQDQLIIFMALASGISRIKTGPVTLHTQTAIHFAEQLAKAKFTVKKSEDEEDASKDTYIIECQGIGMTNPNL

Gene
RTCA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Homo sapiens
Length
366 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
39.337 kDa
Sequence
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL

Gene
RTCA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Macaca fascicularis
Length
366 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
39.41 kDa
Sequence
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGRLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFRFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTDRGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDASKDTYIIECQGIGMTNPNL

Gene
RtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Mus musculus
Length
366 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
39.254 kDa
Sequence
MEGQRVEVDGGIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMVRDLCGGHLEGAEIGSTEITFTPEKIRGGVHTADTKTAGSVCLLMQVSMPCVLFAASPSELRLKGGTNAEMAPQIDYTMMVFKPIAEKFGFTFNCDIKTRGYYPKGGGEVIVRVSPVKRLDPINLTDRGSVTKIYGRAFVAGVLPLKVAKDMAAAAVRCIRKEIRDLYVSIQPVQEARDQAFGNGSGIIIVAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIIFMALANGISRIKTGSVTLHTQTAIHFAEQLAKAKFTVKKSEEEEDATKDTYVIECEGIGMANPHL

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Length
361 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.29 kDa
Sequence
MGSGEWVVVDGSMGEGGGQILRTAVALAAVLGRPLRIVNIRAKRRPPGLRPQHLTAVRAVAAISGGRLRGAEVGSTSLEFTPGRVRGGRYRFDVGTAGSVALIIQALAPLLAYSDSPVEVELTGGTDVPMAPTIDYMREVFASILAMLGYEIEIRVLRRGHYPRGGGRVVVRVPDPPGGFRARSFVERGPLKGVYVRSHAVKLPGSIAERQARSAASLVRERLGVDPIVEIEAYKPHRDPHLGPGTGVLVWAVFGETVMGGDSIGKKGKPAEVVGREAAESLLEDMATGAALDRHMSDMAPVYLALAGGVSTVFGARLTGHASTILELLRIMVDGFEYRILEGGLERPFKAELRGAGVSPR

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Length
361 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.839 kDa
Sequence
MTLLRIDGSYGEGGGQIIRTALSLAALTGTAVRLENIRARRRKPGLAAQHLTAVKAVALLCDARIGGAELGSQTLEFIPGRPVRAGDYTLDVGEAREGGSAGAVMLVLQTVLPPLALAEGASTVSLRGGTHVPMSPPFDYVREVWLPTLARMGVRAELSLVRSGWYPVGKGEVRLVVAGGRRSLEALKARHRGTLQAVTGRALAANLPAHIPERMAARARAVLADAGIAAAIEPAVLQAACAGAGLFLTARYDHCLAGFTALGRRGKSAERVAEEACGALLAHHRSGAALDQHLADQIVLPAALCREESLFSVERITPHLTTNAWVVDRFGLARVDVRLAECGTGLVRIHGNPAGVCHAHP

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Aquifex aeolicus (strain VF5)
Length
360 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
40.583 kDa
Sequence
MGEFLELDGSYGEGGGQIVRTALFLSTLLQVPVRIYNIRAKREKPGLKRQHLNIVKLLKRFAKAKVKGDELGSIELEYKPQKLKPGYYEVNFDTAGSIPLFLQTILPLSLFVPGEVVIKVIGGTDVPKSPTIDWVRFVFLHYIYKVPEFIRLEVLKRGFYPAGGGIVQLSVRNKLEKQPENLQEVKEYLKDKVNLYRTERGEIRKIHVFSVAHEELRERKVAERQAKGAIEALKNLGYPEPEVYRQYANANSIGTSITIWLEDTKGNVLGADNLGKKGKLAEVVGAEAVKKLHEDWSSGATVDRHLADHLIPLMALVGGEIRVPQFTGHLLTNIWVCEQFLGKIFEVDEKEKIVRTQGIS

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
Length
359 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.709 kDa
Sequence
MIVIDGSIGEGGGQILRTTLALAALLGKPVRIVNIRAKRPRPGLQRQHLTSVKAVAELASARVEGLELGSTTLVFIPRGLRSGRFYFNIGTAGSITLVLQALLPVTAFAPGPVEVEIVGGTDVPWSPPIDYVRFVLRKLLAMFGFEFEIIVKRRGHYPRGGGRVVLRVTQPPHVLKPVKLEERGKVLRVEGLSHAVRLPRHVAERQARSAEAVLRSKLPGVPISIDLEWYEPSRDPHLGPGSGVVVWAVAEHSVLGSDSLGAKGKPAEAVGREAAEKLLEDLATGTALDRHASDMLIPYAALACGESILGGARLTMHAWTNIEVVKMLVPGAEMEFIEGGKLNEKFKLRVKGICYKPSS

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)
Length
357 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
39.042 kDa
Sequence
MSILEIDGSIGEGGGQILRYALALSALTLKPIRVYNIRAKRDNPGLRPQHLTAVEVLKEVTGAEVENAKVGSMEILFKPTSRRSGEMEIDIGTAGSISLVLQAMLPVLLFAEGDSRARLKGGTNVPWSPPIDYIKHVFLYNISHMGVRANIEVVRRGHYPRGGGLVNVEVKRVEEALKPLMIVRRGRIRGFRIHSHCVKLPAHVAVRQCESARRILSGIFKEKITEEIETYPPDKDPHLGPGSGILIYVEAEPGIRLGSDSLGEKGKPAERVGEEAALILIEELETGMAFDRHMGDMLIPYLFLAKGTSRIGVSMITLHLLTAIEVGKLFFPEAKVEVDGELGKPGIITIQGVGYKP

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Length
357 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.755 kDa
Sequence
MEIIEIDGSMGEGGGQILRYSLGFSAVTLKPVRIYNIRAKRSNPGLRPQHLTAVKALQMITDAVVKGAKVGSMEIYFEPKRRKPGNYRFNIGTAGSTTLVIQAILPALLFSKGYSSVEIIGGTDVPWSPPIDYMRYVFIYNLRFFGVDVEIELYRRGHYPRGGGRVVLKVKPLLGKMKPINIVERGKLISIYGISHAVRLPRHVAERQARSAATVIREKLGVEPNILIESYPPGRDPHLGPGSGIVLYADVEAGTRLGGDALGARGKRAEIVGREAAEKLIDELSSGMAFDSHMGDMLIPYMFLAGGESIAGVSKLTNHTLTAIEVSKIFLPNSKVSIVGNKGEKGIIRIHGVGLSP

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Koribacter versatilis (strain Ellin345)
Length
355 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.475 kDa
Sequence
MRCGPKGLNMIVIDGSQGEGGGQILRTALSLSMVTGQPFTIEKIRANRERGGLLRQHLTAVLAAAEISGANVTGAELGSRTLTFAPQRVTPGDYSFAVGTAGSATLVLQTLLPALMLANKPSNVVVEGGTHNMAAPPFDFLAKTFAPIIESMGPKLKLTLDRYGFYPAGGGKITAEIEPVEKLKQLELLDRGEVLQQNAVALLAHLPRHIADRELETASNILGLAPESTRILGTKNSAGPGNALMIEVQTERHTEIFTAFGKVGISAEKVAEEAAVAAAQYVASSAFACEHLADQLLLPIALAGGGSFTAVRQTMHARTNIEIIRLFLPVSFEISEEENCARVALSTRDRAGVSA

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
355 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.735 kDa
Sequence
MIEIDGSYGEGGGQVVRTAVALSAVTGKDVKVTNIRKNRPNPGLKQQHLKALETAARICEARVSGLFPGSSELFFSPVEIKGGKYEVDIGTAGSITLLLQSLMPALPFAKEKVKLTIKGGTDVAWSPTIDYLQHVTLRALEQLGYAGIVTLKKRGYYPRGGGEVSAVFEPCKLRSFHFRRVKENRRTGEARREEETRNEGRNQNQRIEIQGISHASNLPAHVPARQAEAAESLLLEAGYGSRTKIQSFELLSTGSGITLWSGYCGGSALGKKGLPAEKVGRRAAEEIILELSSKAPVDVHLADQLIPYMALAGNSSYTVRELTLHAATNIWVTEQFLDVKFRIEEKEGLFEVSVD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)
Length
354 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.55 kDa
Sequence
MITIDGSMGEGGGQILRTALALSIITGKPFRIINIRARRSNPGLQPQHLASVMAAARISNAKVDGAYKGSLSLTFEPGDVKCGDYSIDIGTAGSISLVLQTLLPVLAVVNCGEVTLDITGGTDVPKAPPIDYVRFVLAHNLSLMGVGIKVELIRRGHYPRGGGKVKVTVKPAGRLKPINITELGELKGIWGLSHAVRLPSHVAVRQAKAAEDYLSKLGLKPSISLEYYEQGKDPHLGPGSGITLWAESTNGQRIGADSLGERGKPAEDVGREAAEALAAVINAGAAFDDHMGDMLIPFLALAEGRSEYTVVNLTSHLSTNISIVKLFLNANIETMNYNKKVKVTINPITAPRKP

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Length
353 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.75 kDa
Sequence
MQEIDGSYGEGGGQLLRTSVALAAITGQSVRVYNIRAKRSNPGLAPQHLTAVKAVAALCRARTEGMEVKSQEIIFRPGPLRGGEYDFPIGTAGSVTLVLQAALPVALACGEKVRMNISGGTDVRAAPPLDYFRYVLLPLVYSMGARAKIEVLLRGYYPRGGGKVVVDVEPCLPLRPVLLNASEGLEGITGFVHISNLPKHIIHRMANGALAELSTFPTPAVGLEVFGKDDAIGEGGAVLLTAHKEHSRLGASAVAERGVPAERLGAEAGRCLREEILSGATLDIHAADQVLIYLALASGVSCFLTRELSSHAATTIWLLEQFLPVRFQVTQEAHLIRVRAKPEFNGMSSFLWR

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Salmonella heidelberg (strain SL476)
Length
353 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.05 kDa
Sequence
MARIIALDGAQGEGGGQILRSALSLSMITGQPFEMSGIRAGRAKPGLLRQHLTAVRAATEICGAQVNGDELGSQQLRFTPGPIRGGEYRFAIGSAGSCMLVLQTVLPALWFADGSSRVEVHGGTHNQAAPSADFICRVWEPLLARMGISQRTTLIKHGFYPAGGGAAATVVEPATSLRGLTLISRGETLRTTAEALLAAVPYHVGEREVATLEAHFPQAEKNVVALEAHFPQAEKNVVALEGGCGPGNALSLMIQSEQLTELFAAFGVKGTSAEAVANQVAHEARRYLASPAAVGEHLADQLILPLALAGEGAFTVARASAHLLTNIVVVERFLPVRFSCEATESGYLVRVSD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Length
353 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.695 kDa
Sequence
MIEIDGSFGEGGGQILRTSVALSAVTLKPVRIFNIRAKRKNPGLRRQHMVAVKALAEMTDAEVRGLELGSTEIVFIPKTLKAGTFRFDIGTAGSVSLVLQAVTPAALFAPGEVRVQLRGGTDVPMSPPVDYLRFVFYPLLERFGAKTELVLKRRGHYPKGGGEVEFASRPVDSLTQWGEVERGEVLKVRGLSHCVKLPKHVAERQAKAAEEVLKKSGLKNVDIDLEWYPPERDPHLGPGSGIVLWAITERSLLGADSLGARGKRAERVGEEAARKLLEDLSTGKALDRHMSDMIVPYVSLACGRTEVGGAALTMHAWTHVHVVKKFLPELEVEISGELNKPFVMRVKGVCWQR

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
352 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.092 kDa
Sequence
MSLIEIDGSYGEGGGQILRTAVGMSALTGEPVRIYNIRANRPRPGLSHQHLHAVKAVAEICDAECEGLEIGSTEIVFEPGKVKGGEYEVDIGTAGSVTLLLQAVKLAAIAADGPVEMEVRGGTDVKWSPPVDYEINVNAHYLDRLGYRYELEVLRRGHYPRGGGIVRARMEPPKRLKPLEAVKFGELESVRGISHCVRLPPHVAERQAKAASEIIERELGIRPEIEIETYPKGRDPHLGPGSGIVLWAEDDQGNRIGADALGEKGKPAEVVGREAAEQLVQRLRTGMALDEHMGDQILPFLAIADGESVFGVTGVDPHLPTNAWVVEKFLPVSVEIRGKEGEPATVEVRPEG

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
352 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.774 kDa
Sequence
MIEIDGSYGEGGGQLVRTAVALSAVTGEEIKVTNIRENRPNPGLKQQHLKALETAAKICGARVSGLSQGSSELFFAPVEIKGGKYNIDIGTAGSITLLLQCIMPALPFVEEKVELTIRGGTDVAWSPTIDYLKHVTLRALEQFGYAGSVTLKERGYYPRGGGSVSAVFEPCKLHGFHFRKTEGNKKTESNPVGEGLKGEKSMMEEIIGVSHASNLPAHVPARQAESARSLFLEAGYDARIDVSSSEFFSTGSGITLWKGYCGGSALGKKGLPAEKVGRQAAEEVIKELRAGAAVDIHLADQLIPYMALAGNSSFTVRELTLHAATNIWVTEQFLDVKFKIKEKEGLFEVSVG

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Cyanothece sp. (strain PCC 7424)
Length
350 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.007 kDa
Sequence
MLDIDGSWGEGGGQILRTTLSLSAITGQPIRLYQIRAGRQKPGLSAQHLTCVRAAATICNAEVRGDKLRSTLLEFIPTRPPQAGHYTFDVMDAQEGGSAGAVTLILQTILLPLAIASEESTVILKGGTHVAWSPPISYIEQVYLPLLSKLGLQTELHLQAWGWYPQGGGEVHLHIKGNCQLQGVELLERGALKQVKGLAVVTELPSHIPQRMAMRCEKLLQQAHVKGYVQPLRAKGVAPGAGVFLTSEYEHICAGFAALGRRGLPAESVAQNAVEQLLSFHQQDAPVEEFLGDQLLLPMILAQSPSQYRVAHISEHLKTNVQTISQFGLAQIDLNLEDRLVFVKPGHNLT

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Length
350 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
38.601 kDa
Sequence
MRVIDGSYGEGGGQILRTAVALSVITGEPIKIINIRAKRSNPGLRPQHLHGILALKELSDAKVKGAKEGSTELEFYPKSTRVRHVKVLIKTAGSISLVLQALLPAMVFAEEEVTFEITGGTDVAWSPPVDYLKHITLYALEKLGIKVEIEIRRRGHYPRGGGFVIGKVYPWGTKRPLVARTFDKIYSFEGISHAVRLPSHVAIRQAKAAKEALERVYPSIPIKIHEEYYEQGKDPHFGPGSGIVIWANTDVLRLGGDALGERGKPAEIVGREAAKALIEQLGPRHAVDKFLGDQLIPFLTFAGGDIWVSEVTKHLITNVWVVEQFFGRVFEMEGEIGKPGKVRVVKKVEL

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Length
348 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.859 kDa
Sequence
MIEIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRKKPGLAAQHLTAVRAAGRICNAQLRGDALGSMLLEFIPGSAVQAGIYTFDVSKAQEGGSAGAIALVLQTILLPLALATGNSQVTLKGGTHVNFSPTVTYIEQVYLPILQRMGVEAQVKLGAWGWFPQGGGEIELQVIGGTQLGGINLLERGELQQVRGIAAVTELPSHIPQRMANRAENLLREAHLKVRVQTLREKGVAPGAGIFLTAEYQNSLTGFGGFGRLRLSAETVAEIACQQLLEFHYTGAAVDEHLADQLLLPATLASQESQYQVAEVSRHLITNAAVIEQFGLAQIRVNEADKIVSVKSLTS

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Length
348 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.637 kDa
Sequence
MINIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICHGELQGDALGSTMLEFIPGGGVKAGNYIFDVSEVQQGGSAGAITLVLQTILLPLALADGDSHITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLGAWGWYPRGGGEVNLQVKGGCQLCGLNLLERGELKRVQGLAVATELPAHIPQRMANRAENLLRTAGLRVSMQALREKGVAPGAGIFLTAEYCNSLTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAVLASESSQYKVAEVSTHLTTNAAVIEKFGLGKITVNQAERVVAIASSKV

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
348 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.36 kDa
Sequence
MAVRIDGSYGEGGGQILRTSIALSALLGRPVEIVNIRAKRANPGLQPQHLTGVKVAALLTDAEVKGAEKGSTRLYFEPKTLKCGNFSIDIGTAGSISLIVQTLAPILLYAPCPTQITVTGGTDVAWAPPIDYMRFVFTKVLERFGAKLSIELIRRGHYPRGGGRAVVRAEPVKRLKAVESEEFGNVVKISGISHAVNLPPHVAERQAKAAREELSKMGLDADIAIEVRNDGLGPGSGVVIWAVSDAGNVIGGDSLGERGKPAETVGKEAAQKLIAVLKTRASVDPHMADMAVLYMALAEGRSRISTSEETMHLKTNMYIIEQFLRVKFSTMEKAGRYTIEVEGVGYNR

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Length
348 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.233 kDa
Sequence
MIVKIDGSYGEGGGQILRTSIALSALLGKPVEIINIRAKRTNPGLQPQHLTGVSAAALLTDADIEGAAKGSTRLYFKPKTLKCGTFNIDIGTAGSISLVIQTLAPILLYAPCPTKLVITGGTDVAWAPPIDYMRYVFVKVLSLFGAKIAIELVRRGHYPRGGGRVIVYVEPIKKLRAVHYVEFGRLVKISGISHAVNLPTHVAERQAKAAKETLAKLGYVAEVEVETRSDGLGPGSGIVLWAESDIGNVVGGDALGERGKPAEEVGREAAERLAAVLKTGVSLDPHMADMAVVYMALAEGRSKMSTSEATLHLQTNMYIVEQFLPVKFKLEKTGARYIIEVDGIGYSR

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Length
348 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.668 kDa
Sequence
MIDIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICHGELQGDALGSTMLEFIPGGGVKAGNYIFDVSEVQQGGSAGAITLVLQTILLPLALADGDSHITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLGAWGWYPRGGGEVNLQVKGGCQLCGLNLLERGELKRVQGLAVATELPAHIPQRMANRAENLLRTAGLRVSMQALREKGVAPGAGIFLTAEYCNSLTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAALASESSQYRVAEVSTHLTTNAAVIEKFGLGKITVNQAERVVAIASDKT

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Korarchaeum cryptofilum (strain OPF8)
Length
348 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.666 kDa
Sequence
MEFIRIDGSYGEGGGSLLRYAIALSSVTMKPVEIYNIRVKRANPGLRPQHLNAVRALARITEATVEGDEVGSTALRFIPRKRAGGSFEIDIGTAGSISLIIQAILPACISSEEEISLRIRGGTDVPLAPPIDYMAEVFLRNMAPLGVRAELKLLRRGHYPRGGGIVELHASPSKLFPIDKVRGEKFDRVLGRCHAVKLPRSVVERISSSAIDTLRKEGLRVEIEEEWSEDGHLGPGAGIVLWTDSNPRIGADELGEKGKPSEVVGKNAASKLLDEIKAGMAFDSHMGDMIIPYLALARGRSRVGISKLTLHAESNIWLVERFLPVKFIVQGGVGSPTVIEVEGAGLEL

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Length
347 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.67 kDa
Sequence
MIRIDGSYGEGGGQILRTAIALSALLGVPVEVFNIRAKRANPGLQPQHLTGVNAAALLTDAELEGAAKGSTRLVFKPKTIKCGGFQIDIGTAGSISLVIQTLTPIALFAPCPVRLSITGGTDVAWAPPIDYMRFVFAPVVGRFGGRVKIEVLRRGHYPKGGGRVEVEVAPVDVLKPVDAVDFGKVLKIRGISHAVNLPAHVAERQARAAAEALAKEGYAADISTEVRNDGLGPGSGVVLWAESDVGNVVGGDALGERGKPAEAVGREAAEKLLTALKSGASVDSHMADMAVVYMALAEGVSRITTPELTLHLQTNMYIVERFLPVKFRVEKLGQRHLIEVNGVGRRR

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta)
Length
347 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.649 kDa
Sequence
MAVRIDGSYGEGGGQILRTSIALSALLGKPVEIVNIRAKRANPGLQPQHLTGVSAAALLTDAEVEGAAKGSTRLFFKPKALKCGTFNIDIGTAGSISLVVQTLAPILLYAPCPTKLVITGGTDVAWAPPIDYMRFVFARYLTRFGARIAIELVKRGHYPRGGGKAVVQAEPAGRLRAVDSVEFGRPAKIAGVSHAVNLPPHVAERQARAAREALAKLGYAAEVEVEARNDGLGPGSGVVLWAESDVGNVVGGDALGERGKPAEEVGREAAEKLAAVLKAGASLDPHMADMVVLYMALAQGRSRLSTTEATMHLQTNIYIVEQFLPVKFKLERAGPRYIIEVEGVGYP

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Ralstonia solanacearum (strain GMI1000)
Length
347 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.97 kDa
Sequence
MNNRLQPAPCIELDGAQGEGGGQILRTALTLSMLTGTPFRIERIRAGRSKPGLMRQHLTAVQAAAEVSGATVEGAEAGSQALAFAPGPIHGGDYRFAIGTAGSCTLVLQTVLPALWFADAPSTVAVSGGTHNRAAPPVDFLIRAWQPLLARMGVTQTLALKRHGFYPAGGGEVLATVTPCAGRLGALHLTERGALRELSGQGIVANVRPGVARRELEALAARVPGVVGSVRELSPAEGPGNALVLDAVHEHVTEVFTGFGERGVPAEQVAHGVASAALRYLHSTAAVDEYLADQLVLPMALAGAGCFTAVTASPHLTTNIAVIEKFLPVHITVQAERDASVVRVQVN

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Salmonella agona (strain SL483)
Length
344 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.124 kDa
Sequence
MARIIALDGAQGEGGGQILRSALSLSMITGQPFEMSGIRAGRAKPGLLRQHLTAVRAATEICGAQVNGDELGSQQLRFTPGPIRGGEYRFAIGSAGSCMLVLQTVLPALWFADGSSRVEVHGGTHNQAAPSADFICRVWEPLLARMGINQRTTLIKHGFYPAGGGAAATVVEPAASLRGLTLISRGETRRITAEALLASVPHHVGEREVATLEAHFPRAEKNVVALEGGCGPGNALSLMIQSEQLTELFAAFGVKGTSAEAVANQVAHEARRYLASPAAVGEHLADQLILPLALAGEGAFTVARASAHLLTNIAVVERFLPVTFNLEEAREMVQVMVSKKDSGS

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Salmonella paratyphi C (strain RKS4594)
Length
344 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.01 kDa
Sequence
MARIIALDGAQGEGGGQILRSALSLSMITGQPFEMSGIRAGRAKPGLLRQHLTAVRAATEICGAQVNGDELGSQQLRFTPGPIRGGEYRFAIGSAGSCMLVLQTVLPALWFADGSSRVEVHGGTHNQAAPSADFICRVWEPLLARMGISQRTTLIKHGFYPAGGGAAATVVEPATSLRGLTLISRGETLRTTAEALLAAVPYHVGEREVATLEAHFPQAEKNVVALEGGCGPGNALSLMIQSEQLTELFVAFGVKGTSAEAVANQVAHEARRYLASPAAVGEHLADQLILPLALAGEGAFTVARASAHLLTNIAVVERFLPVTFNLEEARGMVQVMVSKKDSGS

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Length
344 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.245 kDa
Sequence
MEWVEIDGSYGEGGGQILRTAVALSVITGKPVRIHRIRANRPNPGLRPQHLHGILALKELSNARVKGAKVGSTVLEFVPGRAEPKHVKVPIKTAGSITLVLQALLPAMAFIGGSFEITGGTDVPWSPPVDYLRNVTLFALEKMGLRAEIELKRRGHYPKGGGLVTGSVEPWESKKPLVALEWNKVDSFAGISHATNLPAHVAERQAKSAEERLREFFNAPVEIETEVSRSLGPGSGIVVWAETDSLRLAGDALGKRGKPAEVVGREAAEELIEQLTPRKAVDRFLGDQLIPFLAFAGGEIGVAEITNHLVTNVWVVERFLGRTFEVEGEIGEPGVVRVVRKAEV

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
343 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.149 kDa
Sequence
MEWVEIDGSYGEGGGQILRTSVALSVITGKPVRIYNIRANRPNPGLRPQHLHGILALKELSNAKIKGASVGSTELEFIPGKAEPKHVRVPIKTAGSITLVLQALLPAMAFIGGSFEITGGTDVPWSPPVDYLKHVTLYALEKMGIKVELEIKRRGHYPRGGGLVVGRIEPWEEKKPLKALKWERIEWFAGISHATNLPAHVAERQAKAARERLSEVYSAPVEIETEVSRSLGPGSGIVVWAETDKLRLGGDALGKRGKPAEVVGREAADELIEALKTGMAADRFLGDQLIPFLAFAGGEVGVSEITNHLVTNVWVVEKFFGNVFEVEGEVGKPGTLRVVKSVL

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O157:H7
Length
342 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.332 kDa
Sequence
MKRMIALDGAQGEGGGQIMRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAASFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGQFTVAHPSCHLLTNIAVVERFLPVRFTLAETDGVTRVMITKLTD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Length
342 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.332 kDa
Sequence
MKRMIALDGAQGEGGGQIMRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAASFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGQFTVAHPSCHLLTNIAVVERFLPVRFTLAETDGVTRVMITKLTD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Length
342 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.971 kDa
Sequence
MKQDVVELDGAIGGGQVLRSALSLSMLTGKTLRIHNIRARRSRPGLLRQHLTAVLAAAQVCGARSTGAELGSQVLSFEPGPIRGGDYRFAIGTAGSCTLVLQTLLPALLRAPQPSRVSISGGTHNPLAPPVDFLQQAWLPQLRRMGGRVELQLLRHGFVPAGGGELEAFIQPSELQPLHLQERGALLGSRAWALSAGLPEHVAERELRRVHDRLQLPREQLTPVLLDEEYGPGNVLLLEFAFEHLTELFCGFGQNSLRAEKVADGAIDQARDWLDSGAAVAEHLADQLLLPMALAGGGSFTTPCMTEHLQSNIRVIEAFLPVRIEARPLSEQVLQVQCHALS

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
342 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.928 kDa
Sequence
MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGTDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVATKYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWAETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEIWVSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVVRRVE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Length
342 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.466 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAATEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPVGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFPLHEQYIHNLPRDQGPGNTVSLEVESENITERFFVVGEKHVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGQFTVAHPSCHLLTNIAVVERFLPVRFTLAETNGVTRVMITKLTD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pseudomonas aeruginosa (strain LESB58)
Length
341 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.621 kDa
Sequence
MRKDLIELDGSEGGGQILRSALSLSMTSGQPLRIRNIRGRRSRPGLLRQHLTAVRAAAEICAAEVEGAELGSRELAFRPGAIRAGDYAFAIGSAGSCSLVLQTLLPALLAANGESRVRISGGTHNPLAPPADFLRDSWLPLLQRMGAEVDLELLRHGFVPAGGGELLARVRPARWRPLQLEHPGAALRRQARALLAGIPGHVGERELERVRQRLGWSDEERQLEFLAEVQGPGNALLLRIDCEHICATFCAFGQAGVSAERVAEQVATQAIGWMESGCAADEHLADQLLLPMALAGAGSFTTPRLSAHLQSNRRVIERFLPVRIGDQALDGGGHRIVITSA

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Length
341 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.637 kDa
Sequence
MRKDLIELDGSEGGGQILRSALSLSMTSGQPLRIRNIRGRRSRPGLLRQHLTAVRAAAEICAAEVEGAELGSRELAFRPGAIRAGDYAFAIGSAGSCSLVLQTLLPALLAANGESRVRISGGTHNPLAPPADFLRDSWLPLLQRMGAEVDLELLRHGFVPAGGGELLARVRPARWRPLQLEHPGAALRRQARALLAGIPGHVGERELERVRQRLGWSDEERQLEFLAEDQGPGNALLLRIDCEHICATFCAFGQAGVSAERVAEQVATQAIGWMESGCAADEHLADQLLLPMALAGAGSFTTPRLSAHLQSNRRVIERFLPVRIGDQALDGGGHRIVITSA

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
341 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.637 kDa
Sequence
MRKDLIELDGSEGGGQILRSALSLSMTSGQPLRIRNIRGRRSRPGLLRQHLTAVRAAAEICAAEVEGAELGSRELAFRPGAIRAGDYAFAIGSAGSCSLVLQTLLPALLAANGESRVRISGGTHNPLAPPADFLRDSWLPLLQRMGAEVDLELLRHGFVPAGGGELLARVRPARWRPLQLEHPGAALRRQARALLAGIPGHVGERELERVRQRLGWSDEERQLEFLAEDQGPGNALLLRIDCEHICATFCAFGQAGVSAERVAEQVATQAIGWMESGCAADEHLADQLLLPMALAGAGSFTTPRLSAHLQSNRRVIERFLPVRIGDQALDGGGHRIVITSA

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pseudomonas mendocina (strain ymp)
Length
341 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.513 kDa
Sequence
MNKDFIELDGAIGGGQILRSALSLSMLTGKPFRIHNIRAKRSRPGLLRQHLTAVTAAAQISSADAEGTQIGSQSLSFAPGAIRGGDYEFAIGTAGSCSLVVQTLLPALLHADQPSRVRISGGTHNPLAPPFEFLERAWLPLLKRMGAQVEIELLRHGFAPAGGGALVMQVTPSALRPLHLETPGPIHSQQATALVADVPGHVAERELARVGKRLKWPEQALKGIWLDKQIGPGNVLLLEIACGEVTELFSSIGQSGVRAERVADQAVDQARQWLHSGAAVDEHLADQLLLPLAMAGGGSFSTTHMSEHLSSNIQVIRQFLNVEIVCTQANERILRVELRQG

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
341 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.167 kDa
Sequence
MITIDGSYGEGGGQILRTSVALSTITGEPVRIVNIRANRPNPGLRPQHLHAILALKHLANAEVKGAHVGSRELVFIPKKLEAKEISIDIGTAGSITLVLQALLPAMVFAREKVKFRITGGTDVSWSPPVDYLSNVTLFALEKIGIHGEIRVIRRGHYPKGGGIVEGYVEPWNEKRELVAKEYSRIIKIEGISHATNLPSHVAERQARAAKDELLQLKVPIEIRTEISRSIGPGSGIVVWAETDCLRLGGDALGKKGKPAEIVGKEAAQELLDQLKPGHCVDKFLGDQLIPFLAFSGGVIWVSEITNHLKTNIWVVESFLGRIFDVDGNVGEPGKIRVIRRV

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Thermococcus onnurineus (strain NA1)
Length
340 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.946 kDa
Sequence
MSMIVIDGSYGEGGGQILRTSVALSVITGKPVRIYNIRANRPNPGLRPQHMHGILALKELSGAKVKGAQVGSTVLEFYPGRARPRHIRVPIKTAGSVTLVLQALLPAMAFIGGSFEITGGTDVPWSPPVDYLRHVTLFALEKMGLRAEIEIKRRGHYPKGGGLVVGRVEPWEERKPLVALEWRHIELFGGISHATNLPEHVASRQAKAARERLSEFYDVPINIYEEVSRSLGPGSGIVVWAETDVLRLGGDALGKRGKPAEAVGREAADELLEQLTSRAAVDRFLGDQLVPFLAFAGGEIKVAEITNHLVTNVWVVEQFLGKIFEVEGEVGEPGRVRVVG

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Salmonella enteritidis PT4 (strain P125109)
Length
339 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.557 kDa
Sequence
MARIIALDGAQGEGGGQILRSALSLSMITGQPFEMSDIRAGRAKPGLLRQHLTAVRAATEICGAQVNGDELGSQQLRFTPGPIRGGEYRFAIGSAGSCMLVLQTVLPALWFADGSSRVEVHGGTHNQAAPSADFICRVWEPLLARMGISQRTTLIKHGFYPAGGGAAATVVEPATSLRGLTLISRGETLRTTAEALLAAVPYHVGEREVATLEAHFPLAEKNVVALEGGCGPGNALLLMIQSEQLTELFAAFGVKGTSAEAVANQVAHEARRYLASPAAVGEHLADQLILPLALAGEGAFTVARASAHLLTNIAVVERFLPVRFSCEATESGYLVRVSD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Salmonella gallinarum (strain 287/91 / NCTC 13346)
Length
339 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.557 kDa
Sequence
MARIIALDGAQGEGGGQILRSALSLSMITGQPFEMSDIRAGRAKPGLLRQHLTAVRAATEICGAQVNGDELGSQQLRFTPGPIRGGEYRFAIGSAGSCMLVLQTVLPALWFADGSSRVEVHGGTHNQAAPSADFICRVWEPLLARMGISQRTTLIKHGFYPAGGGAAATVVEPATSLRGLTLISRGETLRTTAEALLAAVPYHVGEREVATLEAHFPLAEKNVVALEGGCGPGNALLLMIQSEQLTELFAAFGVKGTSAEAVANQVAHEARRYLASPAAVGEHLADQLILPLALAGEGAFTVARASAHLLTNIAVVERFLPVRFSCEATESGYLVRVSD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
339 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.458 kDa
Sequence
MARIIALDGAQGEGGGQILRSALSLSMITGQPFEMSGIRAGRAKPGLLRQHLTAVRAATEICGAQVNGDELGSQQLRFTPGPIRGGEYRFAIGSAGSCMLVLQTVLPALWFADGSSRVEVHGGTHNQAAPSADFICRVWEPLLARMGISQRTTLIKHGFYPAGGGAAATVVEPAASLRGLTLISRGETLRTTAEALLAAVPYHVGEREVATLEAHFPQAEKNVVALEGGCGPGNALSLMIQSEQLTELFAAFGVKGTSAEAVANQVAHEARRYLASPAAVGEHLADQLILPLALAGEGAFTVARASAHLLTNIAVVERFLPVRFSCEATESGYLVRVSD

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
339 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.505 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSALTKKPFRIYKIRANRPKPGLQRQHLTAVEAVKKLTNAKVKGDFVGSTELVFEPEDIVEKGDFEFDVGTAGSVTLILQTILPLLINRNIKVTIKGGTDVPKSPSIDYIRLTFLSLLEKIGIRVNLILIRRGHYPEGGGEIKITEVKGNPSSFSLMERGELLMIKGISHVSSLPSHIAERQAKSAKEFLLSKIKIPVEIEIDVRENERSKGSGIALTAIFEKTFLGSDSLGEKGKRAEIVGEEAAKSIYEEIISNATVDRHMSDMLMLYASLYYGEYIGSELTSHARTNSEIIKKFLNVNIQISGEKPFIFRAKKEL

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Length
339 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
34.879 kDa
Sequence
MHVLDGSSGGGQLVRTALTCAAVSGESFRMRYVRRARSNPGLQAQHCAAVNAVADICDAATDGVEVGSEAFSFEPEVAAEEADDDEEPTLGGTTSVEVGTAGSIPLVFDSLLPLAGALDEPITATLTGGTDAKWAPPMDYFQHVKLPLLREHGIDATVSVDRRGFYPRGGGEATLTVEPSTPTPITLTERGDREALTAYSVAESSLADDEVAEQQATAAAPDAAHEIAYTDADSAGSAVVLAAEYEHSRAGFAALGERGVSADAVGENAADALAAFESGPGAVDSHLADQLVPVVAVAGGEVRAPEVTTHIETCVDLLAEFDYDIDIEHTDDGAVVLSA

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
339 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
34.879 kDa
Sequence
MHVLDGSSGGGQLVRTALTCAAVSGESFRMRYVRRARSNPGLQAQHCAAVNAVADICDAATDGVEVGSEAFSFEPEVAAEEADDDEEPTLGGTTSVEVGTAGSIPLVFDSLLPLAGALDEPITATLTGGTDAKWAPPMDYFQHVKLPLLREHGIDATVSVDRRGFYPRGGGEATLTVEPSTPTPITLTERGDREALTAYSVAESSLADDEVAEQQATAAAPDAAHEIAYTDADSAGSAVVLAAEYEHSRAGFAALGERGVSADAVGENAADALAAFESGPGAVDSHLADQLVPVVAVAGGEVRAPEVTTHIETCVDLLAEFDYDIDIEHTDDGAVVLSA

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.912 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGEYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMCGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFKVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.934 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAATEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSSTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKMGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLVGSFSLHEQNIHNLPRDQGSGNTVSLEVESENITERFFIVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLSVRFSLVEADGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O45:K1 (strain S88 / ExPEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.896 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGVHQQTTLLRHGFYPAGGGVVATEVSPVASFNSLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGTGEFTVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli (strain 55989 / EAEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.91 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLLFRPGTVRGGEYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFKVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.903 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGLPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVTSFNTLQLGERGNIVRLRGEVLLAGVPRHVAEREIATLAASFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFGLVEADGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O81 (strain ED1a)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.911 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGVHQQTTLLRHGFYPAGGGVVATEVSPVASFNSLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLQTNIAVVERFLPVRFSLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O8 (strain IAI1)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.955 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGEYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVSRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFKVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.903 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli (strain K12 / DH10B)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.903 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O9:H4 (strain HS)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.96 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKMGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O1:K1 / APEC
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.896 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGVHQQTTLLRHGFYPAGGGVVATEVSPVASFNSLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGTGEFTVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.826 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGVHQQTTLLRHGFYPAGGGVVATEVSPVASFNSLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAASFSLHEQAVHSLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGTGEFTVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.949 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLPMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLARIGVHQQTTLLRHGFYPAGGGVVATEVSPVASFNSLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLQTNIAVVERFLPVRFSLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.96 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKMGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli (strain K12)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.903 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.108 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITDIRAGRAKPGLLRQHLTAVKAATEICRATVEGAELRAQRLIFRPGTVRGGDYRFAIGSAGSSTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKMGIHQQTTLLRHGFYPAGGGVVATEVSPVALFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRISAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSLVEADGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli (strain SMS-3-5 / SECEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.921 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGLPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKMGIHQQTTLIRHGFYPAGGGVVATEVSPVALFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLVGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFGLVEADGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia coli (strain UTI89 / UPEC)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.896 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGVHQQTTLLRHGFYPAGGGVVATEVSPVASFNSLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGTGEFTVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.892 kDa
Sequence
MKRMIALDGAQGEGGGQILRAALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGAVRGGEYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Shigella boydii serotype 4 (strain Sb227)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.92 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRPGAVRGGEYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFGLIEIDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Shigella sonnei (strain Ss046)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.982 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAAAEICRATVEGAELGSQRLVFRLGTVRGGEYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASPAVVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFGLIETDGVTRVSIE

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.929 kDa
Sequence
MKRMIALDGAQGEGGGQILRSALSLSMITGQPFTITGIRAGRAKPGLLRQHLTAVKAATEICGATVEGAELGSQRLVFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGTDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVQEVKRYLASPAAVGEYLADQLVLPMALVGAGEFTVAHPSCHLLTNIAVVERFLQVRFCLIETDGVTRVSIK

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
338 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
37.229 kDa
Sequence
MDFIVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGEVIFEVKPSKIKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIECSKGISTGAGIVLWNDTLGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAFGKGIVGVSEITNHTKTNMWVVKHFLDVDFEIKEYKENNCNGFTIEVV

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.845 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVRAMKMISNAETKGDEVGSKELTFIPHEIKGNSIIDIDIGTAGSVTLIMQTMIPAIINKNMRIKIKGGTDVPKSPTIDYIRLVYLEILRKIGIESKVNLIKRGHYPEGGGEVIIENVNGNPSDFSLLELGKLIMIKGISHVSSLPSHIAERQKDSAKAILSKLGVQIEIETDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARKLIDNLNTKAAVDVHMSDMLMIFTSLFGGEYIGAELTSHAYTNMEIIRKFLDVKIEISGKRPFRFKAKIF

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfolobus islandicus (strain M.16.27)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.697 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNINIDIDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSARELLSKLGVPIEIQTDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILIDNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.685 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNTNIDIDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSAREILSKLGVPIEIQTDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILIDNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.685 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNTNIDIDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSAREILSKLGVPIEIETDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILINNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.697 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNINIDIDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSARELLSKLGVPIEIQTDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILIDNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.717 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSIITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNTNIDMDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSAREILSKLGVPIEIETDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILINNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.685 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNTNIDIDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSAREILSKLGVPIEIETDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILINNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
337 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.932 kDa
Sequence
MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISNGTLRGDELGSMELEFSPGRVTGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGGTDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEGGGRVHAIIEPSELRPITLEESEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLWAEGNTRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSRVRTCELTLHAETNIILSEKITGRRFRVEGERGGPATIEVL

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Length
335 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.732 kDa
Sequence
MIEIDGSFGEGGGQILRTSLTLSSLTKKPFRIYNIRANRPKPGLQRQHLTAVNAVKILTNATVKGDYVGSTELIFSPGDIQEKGDFVFDIGTAGSTTLILQTILPLLLNRKLTVTIKGGTDVPKSPSIDYIRLVFSKVLERIGISFNVELIKRGHYPEGGGEIRISNVRGEPQRFSITEFGQLEGFVGISHVSSLPVHIADRQKSSAEKILRRLKDKIDIRLDVREGEISKGSGICLSAIGKYGIIGADALGERGKRAETVGEEAALKLLEELKTNAAFDSHMGDMLMLYASLYQGEYTASKLTLHSITNEKVIRKFIDIKGEIKGSSPFLFRVQ

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Length
334 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
36.271 kDa
Sequence
MLEIDGSFGEGGGQILRSSLALSSLTGKGFRIRGIRAKRKNPGLQPQHLTSVRVMKMLTNARVSGDYLGSTELEFEPGEVVEGSFTVDVGTAGSVSLIAMTAIPLMINRRISLRIRGGTDVPLSPPVDYMRLVFIPLLEKMGITGKIEVKRRGHYPEGGGEVEVYGFRGEPRDLVLDSFGELREITGVSHVTSLPAHIAKRQIQGVMEVLREFNVPVKVEEEVSNEGSRGTGIVLSAHGLSIMGASSLGEKGITAENVGRKAGTELLKELKTGAAVDSHMGDMLVTFSAFANLEYTGSLLTQHTETNIEVIRKFLEIDVKIEGRSPFKLRLKRK

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)
Length
332 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.742 kDa
Sequence
MIEIDGSYGEGGGQIVRTSVALSTLTGIPVRIKNIRRNRPRPGLAAQHVRAIEALAQISRAETRGVHLGSEEIEFIPGRISAGSYDVDIGTAGSVTLLIQCLLPALTAAEGPVTVTVRGGTDVRWSPTVDYLEHVALPAMHLFGVTATFRCERRGYYPRGGGVVVLSTRPSRLRPARLELIEEGICGISHCGSLPEHVARRQADAALELLKEKGYDARIDIQTMSSSSPGSGITLWSGFRGSSALGERGVRAEDVGREAAKALIDELKSKASVDVHLADQLIPYIALAGGEYTTREISSHTRTNIWTAQRILRCRIDIDEGEVFRIHSTGSG

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
331 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.884 kDa
Sequence
MLEIDGSYGEGGGQLVRTAVALSAVTGQGIRITNIRKNRPSPGLKQQHLKALETAARICRAQISGLFPGSTEISFVPVEIEGGKYDIDIGTAGSITLLLQCIMPALPFAKEKVELTIKGGTDVAWSPTIDYLQHVTFRALEQLGYSGSITLKEHGYYPKGGGKVSAYFKPCRLREFHFLKEKEDIKGSSHASNLPAHVPLRQAEAASKRLMEAGYPSLIETQSFEAFSIGSGITLWIGYIGGSALGERGLPAEKVGKNAADEIIPELRSGASVDTHLADQLIPYMALAGNSSYTVRELSLHTTTNIWVTEQFLDVKFRIEKKEGLFEVSVS

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Length
331 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.548 kDa
Sequence
MIDIDGSYGEGGGQIVRNAIALSAVTGKATSIKNIRKDRPNPGLSAQHVKAIGIAALLCDAKVEGIKIGSTNIAFFPQEIRGGKYTIDIGTAGSIALLLQCIMPIATYSNTNIKLEIKGGTDVSWAPSIDYLKNVTLSALSKMGYRCNIDILKRGYYPRGGGIVNAIIEPSHLVPDRFSEERGTIRGISHCSNLPEHVAQRQADKAKAILENAGHECSIETCRTDFTSTGSGITLYCGMKGSFVPGKRGTTAEKVGNDAATSLLDELLTPSSVDIHLADQLIPYLGLAEGGSFTVKEISPHTKTNIWVTEKFLDVKFKIEKRNDIVKISIQ

Gene
rtcA
Protein
RNA 3'-terminal phosphate cyclase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
328 amino acids
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
Similarity
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Mass
35.454 kDa
Sequence
MIEIDGSFGEGGGQILRTAVALSCVTGKAVRIRNIRANRPKPGLAAQHLKGIEAAKIISNAEVEGLRIGSTEIVFNPGSVRGGNFRVDIGTAGSVTLIFQTVLLPLLFADRDSTLTVTGGTDVAWAPPVDYFKNVTLRALREMGAECELEVLKRGYYPKGGGMVRLTVRPAEMKGVVYERIDEIVRGVSHCQNLPGHVAERQASSARNFLEERGIRAEIRTEVLKGLSTGSGIVLWSGYKGGSALGERGKRAEVVGQEAAESLYRELMSDAAFDAHLADQVMPFAAMARGRTEYTTSEVTMHQKSNAYVINTFLGKVVKFEGNKIIIK