Protein
Anti-sigma factor RshA
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function
An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. RshA and some peptides derived from it inhibit the sigma factor activity of SigH. Probably releases SigH during oxidative stress (By similarity).
Similarity
Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily.
Sequence
MSENCGPTDAHADHDDSHGGMGCAEVIAEVWTLLDGECTPETRERLRRHLEACPGCLRHYGLEERIKALIGTKCRGDRAPEGLRERLRLEIRRTTIIRGGP