Protein
Anti-sigma-I factor RsgI4
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)
Function
Anti-sigma factor for SigI4. Negatively regulates SigI4 activity through direct interaction. Binding of the polysaccharide substrate to the extracellular C-terminal sensing domain of RsgI4 may induce a conformational change in its N-terminal cytoplasmic region, leading to the release and activation of SigI4.
Sequence
MNLGVVIKIKRKKAIIVTETGEFKAVNARNGMFLGQKILFDQQDVIENNRNGIGLAYSAAIAGMVAVFVFMFTYFGLHNFNGTFAYVDVDINPSVEFAVNRDGIVVNAEPLNDDGRKVLEELIYKDALLEDVILDLVDKSRKYGFIEDNDRKNIILISAALNSDEQEQRNDFEKKLVDNLMPELENLDVNIEMRFVIASKEQRKKAQENKVSMGKYMIYEMARRQGEKLTLESIMSETLENLLLGQDFGVIETEKTPVNTPVKSTATPTKALAAEITPTKTPEQVVMTPANTPAKPTAAPTKAPAAVAVTSAKTPERATTVPVNTPVKPTDAPTKSPATATATATRAPVKATATPAKTLKPSDTPVKTPDGEQSVKVRFYNNNTLSETGVIYMRINVINTGNAPLDLSDLKLRYYYTIDSESEQRFNCDWSSIGAHNVTGSFGKVNPSRNGADTYVEIGFTKEAGMLQPGESVELNARFSKTDNTQYNKADDYSFNSHYYEYVDWDRITAYISGILKWGREP