Protein
50S ribosomal protein L12
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes.
Similarity
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Sequence
MEYVYAALLLHSVGKEINEENLKAVLQAAGVEPEEARIKALVAALEGVNIDEVIEKAAMPVAVAAAPAAAPAEAGGEEKKEEEKKEEEEKEEEVSEEEALAGLSALFG