Protein
rRNA methyltransferase 3B, mitochondrial
Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1485 (Gm1485) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Similarity
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Sequence
MATRIASMRFRCALFQSALTLGRNEVNIKRYVRRRRAVSGVVSVNEPTEISEGVISQTSERSSQHNNDITRNTDKSSIENPVSPNNSQPVQFSHINRQKVINLTSRTRFGEVDGLLYEKLHPGDKSLAKLARIAGSKKLREHQVVLEGKHLVCSALDAGAEAQTLYFSSVDALRELPLDKLRQTNVVKVKMEDAQVWSELDTSQEIIAIFKRPEASRLTFSEEKYGRAVPLTLICDTVRDPGNLGSVLRSAAAAGCHSVLLTKGCVDIWELKVLRAAMGAHFRLPIIPNLTWTDISNHLPKTSTVHVADNHSTTMGKHNDNTTPQKHRRPSDYGWVKGHQYQSKAHDDDDANDLCSLEDYCDENSKSLETQLYYTDWVAGHTSLIIGGETHGLSREALQLAERTSGRRLLIPMVDGVDSLNSAIAAGVLLFEGRKQLLSLEKIRV