Protein
E3 ubiquitin-protein ligase listerin
Organism
Dictyostelium discoideum
Function
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdcD/CDC48 recruitment for extraction and degradation of the incomplete translation product.
Similarity
Belongs to the LTN1 family.
Sequence
MGKDRDKGFRGAKYNPSSSGEANTLMGSQSSGFIGFSAFSSNLTNATDPDYYQVEPEYKVLLKKLQKKDSISRIKGLEELNSKFQKINIEDAEFNISSISPLMNAWEFMYKRLVNDDDRNVRDLASQCLGSIGSRIGKHLGPHVKQLLGPWIVAICDQNDQSINNALLSFQNIFPEKKRKDVFKFGHDEALTYLCENLQETPQTIGDSKSISQEILQERYERCISNSLLAIEYLINNTTATATDSSSSSSTTTTTTTTNNTGNTEIYEKIFESQFFSFFQSKSSNIRKTAYRVLTTVIKKLAGYVEKNFKDFSSKVLGLFSEKDSSTHLYMWDAIISFLQQYGDKAWSNVDVRKHVLPRLWAFLRSGCYGSFELSYPSILPLLTFIPNSIVIGSPSPSPSPSPNTNIDIGFFKELFTNLEKGLEVVDNPRQYGNPNSVDRPSNLLLSCYLECLIYSSKKWGQQYQQINDYLIDTLLFNFYNNHFNLEHSCFSEKLFIEKLLESTIKLANLSNSNLLKIQNLFNSNSFINFNNKENLLNNNEPITTDNNNNNNNNSSPIIKKQEKIIQPISKETLISRLNTFIIVCSNNNNSNNSNNNNVIQVIIKRLFNLACDNLNSNQELSIKILDFILGNYKIDQIISNGLDDIKKIITQLALALNESLLSTGGLNLGVGGDLVSVIVGLLALVPDEDEIKLIWSQILQIFLDSINNNNNNSKKKNNRSNLITNTTNSLVHLINSASNKINRNLLLSTTLFKSIKIQDKKQLQLIKSILFNNNNNNNNEFSPIIPNESVELLIKWVYNKLVDIINTMVQLNLVFNDNDKGGDNNNDDDSDDNDVSIDYLVELSKLLFSSRFKSKSLESLLIEWCKFNIEINNRPSLSGFKSKCNSIDEYLFSTTSNIENDKFILSLLIESIDRNSSTIITNDNLNLNFLSNCAIKLIKSGSYRHDENGDDDDDDDQLYSYFIKEFTSNQLVINSKDQIKISWFRYNRITPFYLLDNYGSNKDNNDSTTFSTDKLLKVLIFNFKVIESFGLEKFIKYSNKENNNSIELLLLNLLFVNGDNQLPPTPTTTTTTTTTITTAVVVSTNEQILEFIENNSTNLLNQFIESLFKFYGDEIFNCNWFNCLVSNVGGDGNNGGIYSVLLALFIDYITSDACLPTSSMKLKSALLNSIKIDNDDNGNSIDSIRQLNLVQILLPILQKESIESYKQWSINQLSQLSSSIPTNFKSISIQLSILSSIVIQRQQQQHQQSQKEQQQITQDDNEILKEKEWLTLLNLIQTIQQWNSKIKSAIIKQQEPELEFLFMKEVELSCLNFILIVIQYISNINSNKSKQPIYLSNNQSQFVQSFLSIWLSNNFTLLSFNKFKSNYYYQQYRNLIEYQSLKIYNIIISNDNIKFIIPGIGDQFQIDHSILILNNWLNRVSNSRSNNNNGNTSDSSYILELYSNTFMKMSNDIKYKISLTKLDNLIELLSTFNYSTSIYNNKGIKKTSYNLLESYFGNENTQLVKSFLLENENNNNNNNNDDGEEKVSFILFSNIFEKILLDFDSTFKPMKKSKDNQLINSISMGQLMCWNLLLLNYSKIDLNRRSILNGWLNDNNIQKVTLFLNQIFPFINKDESPLTTTTTTTDNNGNNYSIEFPFSIIDNDQLITYRMIQKLCSNCFYSLVNYLPSMVRRWADDNSTNSKMNQQIQSYITRFISPIIIQNEIQRVNSYRCTDSDSSDAKFQIKGSTSSKEVTASYEKDEMTISLVLFISDNYPLRVLTVEFSKRVGVSESQWRQWLLSMTSLLLTQDGTVLDACLLWKNSLDKHFQGVEVCPICYSMFHNGTIPKFQCKTCKNKFHAGCIYKWFQTSHKSNCPLCQTDLS