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rnf152-a

Gene
rnf152-a
Protein
E3 ubiquitin-protein ligase rnf152-A
Organism
Xenopus laevis
Length
203 amino acids
Function
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.
Similarity
Belongs to the RNF152 family.
Mass
22.671 kDa
Sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKRTCCSVCLQQMRACQKDLRCPWCRGVTKLPPGYSVSQLPDDPDVVAVITIPHASENTPVFIKLPSNGCYMWPLPVSKERALLPGDIGCRLLPGNQQKPVTVVTMPMEQQPLHGNIPQDIVEEEHERRGVVKSSTWSGICTVILVACVLVFLLGIVLHNMSCISKRFTVISCG