Protein
Dual-specificity RNA methyltransferase RlmN 2
Organism
Myxococcus xanthus (strain DK 1622)
Function
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
Similarity
Belongs to the radical SAM superfamily. RlmN family.
Sequence
MSETSATSLPVTEPLPAPAPAKLVDVASLSLEALSRFVTEELGERAFRAPQIYRWLHQRGATSFDEMTDLSKVLREKLRARAEIVPLVKDCELRSTDGTIKYRWKTRDGRYIESVYMPTEDRRTLCVSTQVGCAMACGFCMTGTMGLKRNLTPSEIVAQVHAVNREVRKNEGHETLRPLSNLVFMGMGEPLHNFENLKTALSILQSEDGPNFSHRHITVSTVGLVPMIERFGKETDVKLAISLNASTDEQRSKTMPVNRKWNIAALLDACRKFPLRQGRRITFEYVLIKGFNDADEDAHRLIELLKGIPVKVNLIPYNENPGLGFHTTGEERAEEFRAILADGHVAAYIRRNRGRDIAGACGQLANRGETQAGTDSTT