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ripA

Gene
ripA
Protein
Ras-interacting protein RIP3
Organism
Dictyostelium discoideum
Length
838 amino acids
Function
Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation.
Similarity
Belongs to the SIN1 family.
Mass
94.059 kDa
Sequence
MSVYCELVDVVQQIRYKTQIFYETFKRDSIAEQIYNFSNESTSEIDPDIPFSKSLDKDYSLLYRPVSTSNNNATSGNSTPPNNAISPNQQQQQQQQAQQQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQQQQQQAQQQQQQAQQQAQVQAQQQQQKPTTATTASTVTTTPQQQPSPNNTTSSCTSSSSGSSSGTTNTTSNTTTSTNTSTVTSATNSSTISSLTSTNASTSSAYSTDQQKPNQPPQQPQNISQPQNISQQQNTNNVQQNNQQQQQQQQQQQQQQTSTSPKKCKIVTFTGTSVKLNSKTLQKSDKTSEKENKQQQPDSSKTQQQQQAQQQQSQQQQQAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPVFIFVKEKVNKVNHDLPITPPPSLLTRLVKPNSEEAEYGDIVPPPGMGLTLSIHTGNTGAGQLKVRVIEKATIIQTIFATLKLHHNNGGTGLIPDPKAYNLRIADSNGRIDQDFPPLDPNQYITKFKDEVLVLCPNPKFDLKKSSSSLSISGGVPQQNNNNSVNSNSSNNSNSSNNNMKSSGFQPQQSQQQQQQTQQTQQTQQQAQQAPQQQQSQQQQQQQQQHPQQIQQQLSSNQLQPDQVGGGGGGGGGNFHRTHHRNVSSGPDAPLVVKITLPDSSITKVVFQKTMLLKDLLESTCKKRKLLISDHYFTLENGQTCNGTLPMEKLGGADLILVSRRPIEQMTALSPTDTDSTGSSSDLQQDIFWYDALAWQYKTYEVTKTKKYGPKQDRIIGIDRERVTNMSPKDTETKRPARLIKDISKVALLEKPKYFTIEYNDGKSYIYEAKTTSLANNYLCK

Gene
ripA
Protein
Peptidoglycan endopeptidase RipA
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
497 amino acids
Function
Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity).
Similarity
Belongs to the peptidase C40 family.
Mass
51.317 kDa
Sequence
MRRTVRALATRVHGRVCAVPLVVGMLLATALYGGGPAAADPAAPDNLATLVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQRELEAGQRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIVNTTATGQALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAESSQDNAVAALKQAQQTFNAQQGELERLAAERAAAQAELDSVRKVSATGNAAPAAAPAAAPAPAAAPAPVPNSAPAPVPGAQPNPQAAAGNWDRAPSGPASSGQNWAVWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRSFLQKLGILPTPTGFTNGAIPRVYGREAVEYVIRRGMSQIGVPYSWGGGNAAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKIPSSQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPVRTSGMTPYVTRLIEY

Gene
ripA
Protein
Peptidoglycan endopeptidase RipA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
472 amino acids
Function
Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.
Similarity
Belongs to the peptidase C40 family.
Mass
49.808 kDa
Sequence
MRRNRRGSPARPAARFVRPAIPSALSVALLVCTPGLATADPQTDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSEGGQGAPPFRMWDPGSGPAGGRAWDGLWDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTPYVVRYIEY

Gene
ripA
Protein
HTH-type transcriptional regulator RipA
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Length
335 amino acids
Function
Under iron limitation, represses the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes.
Mass
36.067 kDa
Sequence
MSLPSIKTTNSYCVVLWCDQGSATINAPDRVVQVMAGDVVLAPHGAFVTGHGVVLPMAFPDFDGGEHTRRLHMGTAWSKRMIFEFSRSLLGETRPSECIAALFDDRARPPRVPEPQAARKVAQKLIAYPADQTPLLEFAQLHNISSRTLQRQFVASTGFTFSEWRAALRVSVAADLLAHDFRIGQVSQMVGFSATSSLTRAFKRHTGDTPSSFTSPRMHAVCEQQPPMIPATTTFARASDDIALWIYSGTATVTTPGYCRFMGAGETVTIPSGTSTRLDVSAGSVALPVPLAAAHDDLTLSDVLAASVNPLAAVELQRLSAQERADVEQVLVPSV

Gene
ripA
Protein
HTH-type transcriptional regulator RipA
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
332 amino acids
Function
Under iron limitation, represses the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes.
Mass
35.447 kDa
Sequence
MNNARLLWCHSGVVNVCLGEQTFTLVAGDLLYAPEGAFWSDTGSGLILELRFRILGIDGPARRIHLGRAWAERMVHEYSRSLFGEDAVSGDVAKLFADRVPTPPLPAPRHARAVAQTLAANPADQTSLEEFAAQRGVSARTLQRQFLSSTGYSFSEWRAAQRVCVATSLLAHDFSIAVVANLVGFSATSSLTRAFRRHIGTTPSAFTTGGIGMGVAGTPAAIPSRTTFAAATRDQQLWIYTGTATVTTPGYCRFLTQGDMATIPAGTHTRIDVAAGSIAIPVPIGVGEQGMSLQEVATLRDQEPSTGLMLVEESRWVHLGRELLPATAPVSL

Gene
ripA
Protein
HTH-type transcriptional regulator RipA
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
331 amino acids
Function
Under iron limitation, RipA negatively controls the expression of the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes. Binds to the consensus sequence in the promoter region.
Mass
36.045 kDa
Sequence
MSSASLLWCHSGVSTVRFGERIFTLVAGDLLFAPEEAQVADDSQGLVLNIRFETLNIMGPARRIHLGHVWNDRLTFEYSRSLFGKETLSPDIARLFTDRVPTPPLPAPRKARAVAQVLVSNPADQTSLEEFAEIQGVSARTLQRQFLKSTGYSFSEWRAAQRVCVAASLLAHDFSISVVANLVGFAATSSLTRAFRRHTGATPSTFTTGQIGMGSAGHPPRIPATTTFAEAHQDQQLWIYSGTATVTTPGYCRFMGQGDMVTIPAGTQTRIDVAAGSIAFPVPVGLDEWGMDLTRVVAVNNQQPKPLTILEQSEWSKLSEELLNTPVPVQM