ripA

Ras-interacting protein RIP3

838 amino acids

Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation.

Belongs to the SIN1 family.

94.059 kDa

MSVYCELVDVVQQIRYKTQIFYETFKRDSIAEQIYNFSNESTSEIDPDIPFSKSLDKDYSLLYRPVSTSNNNATSGNSTPPNNAISPNQQQQQQQQAQQQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQQQQQQAQQQQQQAQQQAQVQAQQQQQKPTTATTASTVTTTPQQQPSPNNTTSSCTSSSSGSSSGTTNTTSNTTTSTNTSTVTSATNSSTISSLTSTNASTSSAYSTDQQKPNQPPQQPQNISQPQNISQQQNTNNVQQNNQQQQQQQQQQQQQQTSTSPKKCKIVTFTGTSVKLNSKTLQKSDKTSEKENKQQQPDSSKTQQQQQAQQQQSQQQQQAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPVFIFVKEKVNKVNHDLPITPPPSLLTRLVKPNSEEAEYGDIVPPPGMGLTLSIHTGNTGAGQLKVRVIEKATIIQTIFATLKLHHNNGGTGLIPDPKAYNLRIADSNGRIDQDFPPLDPNQYITKFKDEVLVLCPNPKFDLKKSSSSLSISGGVPQQNNNNSVNSNSSNNSNSSNNNMKSSGFQPQQSQQQQQQTQQTQQTQQQAQQAPQQQQSQQQQQQQQQHPQQIQQQLSSNQLQPDQVGGGGGGGGGNFHRTHHRNVSSGPDAPLVVKITLPDSSITKVVFQKTMLLKDLLESTCKKRKLLISDHYFTLENGQTCNGTLPMEKLGGADLILVSRRPIEQMTALSPTDTDSTGSSSDLQQDIFWYDALAWQYKTYEVTKTKKYGPKQDRIIGIDRERVTNMSPKDTETKRPARLIKDISKVALLEKPKYFTIEYNDGKSYIYEAKTTSLANNYLCK

ripA

Peptidoglycan endopeptidase RipA

497 amino acids

Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity).

Belongs to the peptidase C40 family.

51.317 kDa

MRRTVRALATRVHGRVCAVPLVVGMLLATALYGGGPAAADPAAPDNLATLVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQRELEAGQRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIVNTTATGQALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAESSQDNAVAALKQAQQTFNAQQGELERLAAERAAAQAELDSVRKVSATGNAAPAAAPAAAPAPAAAPAPVPNSAPAPVPGAQPNPQAAAGNWDRAPSGPASSGQNWAVWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRSFLQKLGILPTPTGFTNGAIPRVYGREAVEYVIRRGMSQIGVPYSWGGGNAAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKIPSSQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPVRTSGMTPYVTRLIEY

ripA

Peptidoglycan endopeptidase RipA

472 amino acids

Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.

Belongs to the peptidase C40 family.

49.808 kDa

MRRNRRGSPARPAARFVRPAIPSALSVALLVCTPGLATADPQTDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSEGGQGAPPFRMWDPGSGPAGGRAWDGLWDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTPYVVRYIEY

ripA

HTH-type transcriptional regulator RipA

335 amino acids

Under iron limitation, represses the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes.

36.067 kDa

MSLPSIKTTNSYCVVLWCDQGSATINAPDRVVQVMAGDVVLAPHGAFVTGHGVVLPMAFPDFDGGEHTRRLHMGTAWSKRMIFEFSRSLLGETRPSECIAALFDDRARPPRVPEPQAARKVAQKLIAYPADQTPLLEFAQLHNISSRTLQRQFVASTGFTFSEWRAALRVSVAADLLAHDFRIGQVSQMVGFSATSSLTRAFKRHTGDTPSSFTSPRMHAVCEQQPPMIPATTTFARASDDIALWIYSGTATVTTPGYCRFMGAGETVTIPSGTSTRLDVSAGSVALPVPLAAAHDDLTLSDVLAASVNPLAAVELQRLSAQERADVEQVLVPSV

ripA

HTH-type transcriptional regulator RipA

332 amino acids

Under iron limitation, represses the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes.

35.447 kDa

MNNARLLWCHSGVVNVCLGEQTFTLVAGDLLYAPEGAFWSDTGSGLILELRFRILGIDGPARRIHLGRAWAERMVHEYSRSLFGEDAVSGDVAKLFADRVPTPPLPAPRHARAVAQTLAANPADQTSLEEFAAQRGVSARTLQRQFLSSTGYSFSEWRAAQRVCVATSLLAHDFSIAVVANLVGFSATSSLTRAFRRHIGTTPSAFTTGGIGMGVAGTPAAIPSRTTFAAATRDQQLWIYTGTATVTTPGYCRFLTQGDMATIPAGTHTRIDVAAGSIAIPVPIGVGEQGMSLQEVATLRDQEPSTGLMLVEESRWVHLGRELLPATAPVSL

ripA

HTH-type transcriptional regulator RipA

331 amino acids

Under iron limitation, RipA negatively controls the expression of the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes. Binds to the consensus sequence in the promoter region.

36.045 kDa

MSSASLLWCHSGVSTVRFGERIFTLVAGDLLFAPEEAQVADDSQGLVLNIRFETLNIMGPARRIHLGHVWNDRLTFEYSRSLFGKETLSPDIARLFTDRVPTPPLPAPRKARAVAQVLVSNPADQTSLEEFAEIQGVSARTLQRQFLKSTGYSFSEWRAAQRVCVAASLLAHDFSISVVANLVGFAATSSLTRAFRRHTGATPSTFTTGQIGMGSAGHPPRIPATTTFAEAHQDQQLWIYSGTATVTTPGYCRFMGQGDMVTIPAGTQTRIDVAAGSIAFPVPVGLDEWGMDLTRVVAVNNQQPKPLTILEQSEWSKLSEELLNTPVPVQM