Protein
GTP cyclohydrolase-2
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Function
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Similarity
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Sequence
MEEVSSHVKSGKPVMILDSEKSAICIPAEVVSGEILNFMMKNCDEIRLALTWKQILNLGLNRFRFQNGNLIPIDPNLEKISAEERAKFIRELVSGNAGDIKYPGRIFVEETKEMGVLERPGIAEACVDLARMAGFAPSAVYAPLMTAEGGVAGEDYALKFAKEHSMPVFRIKDMIEFRIKSEKIVERVIEATLPTKFYGTFRAVGYKTPLGEIVALVKGRVDEGDVLVRIHSECLTGDVFHSLRCDCGDQLENALKMIDREGKGVAIYMRGHEGRGIGLINKLMAYKLQEEGKDTVDANIELGFPPDMRSYGIAAQILMDLKVKSIRLLTNNPLKIEELKKYGFKIVREPIEVEPCEVNLPYLKAKKDKMGHLICFND