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rho-1

Gene
rho-1
Protein
Ras-like GTP-binding protein rhoA
Organism
Caenorhabditis elegans
Length
192 amino acids
Function
Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation (PubMed:24016757). Also required for ventral migration of P cells during larval development (PubMed:11687661). Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development (PubMed:16921365). In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology (PubMed:21387015). In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89 (PubMed:18801371). Association with the oxidase bli-3 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity (PubMed:28085666).
Similarity
Belongs to the small GTPase superfamily. Rho family.
Mass
21.635 kDa
Sequence
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVRHFCPNVPIILVGNKRDLRSDPQTVRELAKMKQEPVKPEQGRAIAEQIGAFAYLECSAKTKDGIREVFEKATQAALQQKKKKKSKCMIL