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rgs1

Gene
rgs1
Protein
Regulator of G-protein signaling 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
481 amino acids
Function
Negatively regulates pheromone signaling during mating. Acts in a negative feedback loop that is essential for the mating process. This loop acts to down-regulate cellular sensitivity to pheromone. Activated by ste11.
Mass
54.362 kDa
Sequence
MPALHNPSSPPPSYEAVTSYRNGNSIDSGDKRQQCSRLMKITSNGRPYSKDFLELFSTMVISTNFSRNRYRFSYVENSCTLLQLLSTLENLQLSQVNRIKSRCGSKVLKSTTKFTIPKTAAKCLCNTFLNARLLQIVNNPSARKFSNEKCLLQLTRKGYSVVSEFLQHNGHNSQAELYASKWNHSAPVIVSISRFSSTDQILKDSSFCEMLLVRMLGSVHEIGKSKNPLLVPVYSVSSPSPKDSLSKVTKYQMFGIDIAEWLMCNTMLLDWSEMETVASDLLIHSYIAYENNSETPLKFSYAKGVSYFLTGKGIATLGWTKNVSNNKLINKINEVEKGSTNKEILETILRKPNLQTYFFEFLKKNFCDENQRFYSEVCEFNDYFSHANETNDHEAIRESFAHACGIYNCFLSSNAPNAVNLPSDLYEKITNHMALAMEVEPLNEWLQLIHILLLEAQTAVLDLMAGDSLLKFLELNGGLGI

Gene
RGS1
Protein
Regulator of G-protein signaling 1
Organism
Arabidopsis thaliana
Length
459 amino acids
Function
Glucose-regulated GTPase-accelerating protein (GAP) for the GTP-bound self-activating heterotrimeric G alpha protein GPA1. Cooperates with G beta-gamma dimers to maintain an unactivated but fully functional pool of GPA1. Phosphorylation-dependent endocytosis of RGS1 physically uncouples the two proteins, resulting in signal activation. Free AGB1 is essential, but not sufficient, for RGS1 endocytosis. Modulates cell proliferation, abscisic acid (ABA) and drought stress signal transduction by acting in a hexokinase-independent glucose-signaling pathway (PubMed:26528314). Involved in the shapes of leaves, the development of floral buds, the elongation of stems, siliques, and hypocotyls, the time of flowering and the regulation of guard-cell K(+) and anion channels. Important for the kinetics of voltage activation of inward K(+) current but not for the current amplitude.
Mass
52.947 kDa
Sequence
MASGCALHGGCPSDYVAVAISVICFFVLLSRSVLPCLIHKAPRTNSSSFWIPVIQVISSFNLLFSIMMSVNLLRFRTKHWWRYCYLWAVWIEGPLGFGLLMSCRITQAFQLYFIFVKKRLPPVKSYIFLPLVLLPWIFGAAIIHATKPLNDKCHMGLQWTFPVAGLHALYVLALIAFTRAVRHVEFRFDELRDLWKGILVSATSIVIWVTAFVLNEIHEEISWLQVASRFVLLVTGGILVVVFFSISSNQPLLSQISLKKRQNFEFQRMGQALGIPDSGLLFRKEEFRPVDPNEPLDKLLLNKRFRHSFMEFADSCYAGETLHFFEEVYEHGKIPEDDSIRRIYMARHIMEKFIVAGAEMELNLSHKTRQEILTTQDLTHTDLFKNALNEVMQLIKMNLVRDYWSSIYFIKFKEEESCHEAMHKEGYSFSSPRLSSVQGSDDPFYQEHMSKSSRCSSPG

Gene
RGS1
Protein
Regulator of G-protein signaling 1
Organism
Homo sapiens
Length
209 amino acids
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
Mass
23.858 kDa
Sequence
MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK

Gene
Rgs1
Protein
Regulator of G-protein signaling 1
Organism
Mus musculus
Length
209 amino acids
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (PubMed:10779778). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity).
Mass
24.107 kDa
Sequence
MRAAAISMPRLNKMPGMFFSASPKDSKEHSHSLLDDKKQKKRPKTFGMDVKTYLRSMIPHLESGMKSAKSKDILSAEEVMQWSQSLEKLLANQTGQNVFGRFLKSEFSEENIEFWLACEDYKKTETDLLHNKAENIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTSFDEAQKVIYSLMEKDSYPRFLKSNIYLNLLNDLQANTLK

Gene
Rgs1
Protein
Regulator of G-protein signaling 1
Organism
Rattus norvegicus
Length
209 amino acids
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity).
Mass
24.096 kDa
Sequence
MRAAAISMPRLNKMPGMFFSASPKDSKEPSHSLLDDNKQKKRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDILSAEEVMQWSQSLEKLLANQMGQNVFGKFLKSEFSEENIEFWLACEDYKKTETDLLHNKAEHIYKAFVHSDAVKQINIDFHTRESTAKKIKTPTPTCFDEAQKVIYALMEKDSYPRFLKSNIYLNLLNDLQANTLK

Gene
rgs1
Protein
Regulator of G-protein signaling 1
Organism
Xenopus laevis
Length
201 amino acids
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity).
Mass
23.299 kDa
Sequence
MPGIFFSHPNALKEVTNKPDEVMAQKKKNFAVPWKNYLKSMLPHLETIKSSSSSSSSDTEKNKLTPNEIIQWTMSLEKLLVSEEGQAVFRAFLKSEFSEENIEFWLACEDYKATNDSEELRCKANVIYQEFIQPNANKQINIDFSTRNSVTKDLLEPTKATFNGAQKMIFILMERDSYPRFLKSEIFFRLAERHHGNNMRG

Gene
rgs1
Protein
Regulator of G-protein signaling 1
Organism
Xenopus tropicalis
Length
201 amino acids
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity).
Mass
23.331 kDa
Sequence
MPGIFFSHANALKEVDNKPDEVMAQKKKNFAVDLKNYLKSMLPHLETMKSSSSTSSSDSEKNKLTPDEIIQWTMSLEKLLISEDGQSVFREFLKSEFSEENIEFWLACEDYKATNDSEELRCKANVIYQEFIQPNANKQINIDFSTRNSVTKDLLEPTITTFNDAQKMIFILMERDSYPRFLKSEIFLRLAERHHGNNVRG

Gene
RGS1
Protein
Regulator of G-protein signaling 1
Organism
Equus caballus
Length
196 amino acids
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity).
Mass
22.544 kDa
Sequence
MPGMFFSANPKDLKGTDQSLLDDKTQKRRPKTFGMDVKAYLRSMIPHLESGMKSSKSKDILSADEVMQWSQSLEKLLANQTGQDVFGNFLKSEFSEENIEFWLACEDYKKTESDLLRCKAEKIYKAFVHSDAAKQINIDFHTRESTAKKIKAPTLTCFDEAQKVIYTLMEKDSYPRFLKSNIYLNLLNDLQANSLK