Protein
Replication factor C large subunit
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Function
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. In conjunction with PCNA stimulates DNA synthesis by PolB, relieving inhibition by replication protein A (RPA).
Similarity
Belongs to the activator 1 small subunits family. RfcL subfamily.
Sequence
MSWTEKYRPGSFDEVVGNQKVIAEIKEWIKAWKAGKPQKPLLLVGPPGTGKTTLAHIIGKEFSDTLELNASDRRSQDALMRSAGEASATRSLFNHDLKLIILDEVDGIHGNEDRGGVQAINRIIKESRHPMVLTANDPYSKRLQSIKPRCRVLNLRKVHTSSIAAALRRICRAEGIECPDDVLRELAKRSRGDLRSAINDLEAMAEGEERIGEELLKMGEKDATSNLFDAVRAVLKSRDVSKVREAMRVDDDPTLVLEFIAENVPREYEKPNEISRAYDMLSRADIFFGRAVRTRNYTYWRYASELMGPGVALAKDKTYRKFVRYTGSSSFRILGKTRKQRSLRDSVAAKMAGKMHISPKVAISMFPYMEILFENDEMAYDISEFLELRDEEIKLFRKRKIKAPKRKKTPRKAEIKVGPLYSQKKDKGADKSINDKATDKSAKTPIKSSKKDDRPRDESSSSSDDKKPKEKQTSLFQFS