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repC

Gene
repC
Protein
Putative replication protein C
Organism
Agrobacterium rhizogenes
Length
405 amino acids
Function
This protein is coded by a hairy root Ri plasmid, it is probably involved in its replication.
Mass
44.321 kDa
Sequence
MMQTGSVTTPFGRRPMTLALVRRQTALADIKQGKTADKWKVFRDASAAMELLGIQSNSLAVLDALLSFHPETELRQEAQLIVFPSNAQLALRAHGMAGATLRRHIAMLVESGLIVRKDSANGKRYARKDGAGQIERAFGFDLSPLLARSEELAMMAQQVMADRAAFRMAKESLTICRRDVRKLITAAMEEGAEGDWQAVEEVYVELVGRIPRAPTLADVESILEEMWMLQEEIINRLEIRDNSENNSTNAAQSEQHIQNSKPESVNELEPRSEKEQGAKPSEIDRARSEPIKAFPLGMILKACPTIGNYGPSGAVASWRDLMSAAVVVRSMLGVSPSAYQDACEAMGPENAAAAMACILERANFINSPGGYLRDLTRRSELGKFSLGPMIMALLKASGQGTLRFG

Gene
repC
Protein
Replication initiation protein
Organism
Staphylococcus aureus
Length
314 amino acids
Function
This protein is probably a specific topoisomerase involved in initiating replication. This protein is specifically required and may be rate-limiting for replication of the plasmid in vivo.
Similarity
Belongs to the plasmid replication initiation factor family.
Mass
37.657 kDa
Sequence
MYKNNHANHSNHLENHDLDNFSKTGYSNSRLDAHTVCISDPKLSFDAMTIVGNLNRDNAQALSKFMSVEPQIRLWDILQTKFKAKALQEKVYIEYDKVKADSWDRRNMRIEFNPNKLTRDEMIWLKQNIISYMEDDGFTRLDLAFDFEEDLSDYYAMSDKAVKKTIFYGRNGKPETKYFGVRDSNRFIRIYNKKQERKDNADAEVMSEHLWRVEIELKRDMVDYWNDCFSDLHILQPDWKTIQRTADRAIVFMLLSDEEEWGKLHRNSRTKYKNLIKEISPVDLTDLMKSTLKANEKQLQKQIDFWQHEFKFWK

Gene
repc
Protein
Repressor protein c
Organism
Escherichia phage Mu
Length
196 amino acids
Function
Promotes latency by binding operators O1 and O2 in the enhancer/operator region, thereby repressing the transcription from the Pe (early) promoter and blocking the expression of the genes required for replication (lytic growth). Competes with DDE-recombinase A for binding to the internal activation sequence (IAS), which overlaps O1 and O2. The outcome of this competition determines if the virus enters latency or starts replication. Makes the cell immune to superinfection by repressing genes expression of any subsequent incoming viral genome.
Similarity
Belongs to the mulikevirus repressor c protein family.
Mass
21.822 kDa
Sequence
MKSNFIEKNNTEKSIWCSPQEIMAADGMPGSVAGVHYRANVQGWTKQKKEGVKGGKAVEYDVMSMPTKEREQVIAHLGLSTPDTGAQANEKQDSSELINKLTTTLINMIEELEPDEARKALKLLSKGGLLALMPLVFNEQKLYSFIGFSQQSIQTLMMLDALPEEKRKEILSKYGIHEQESVVVPSQEPQEVKKAV

Gene
repc
Protein
Repressor c protein
Organism
Escherichia phage D108
Length
174 amino acids
Function
Promotes latency by binding operators O1 and O2 in the enhancer/operator region, thereby repressing the transcription from the Pe (early) promoter and blocking the expression of the genes required for replication (lytic growth). Competes with DDE-recombinase A for binding to the internal activation sequence (IAS), which overlaps O1 and O2. The outcome of this competition determines if the virus enters latency or starts replication. Makes the cell immune to superinfection by repressing genes expression of any subsequent incoming viral genome (By similarity).
Similarity
Belongs to the mulikevirus repressor c protein family.
Mass
19.518 kDa
Sequence
MMSFEIKEWFNAKELEGMPGVPKLATNITRKAVAEDWVKRQRHGGKGVAYEYHINSLPEETRRAIKGASLSDKPVHTSIVHTVDERLIYAMSFLTPDEQAAAVEIIRVAGIKGLMPTIVSKDKALEALGITVEQQKTLQTLQALPPEKVREILSQYEGKEHNFPVRENDVKKAV