rent1

Putative regulator of nonsense transcripts 1

1097 amino acids

RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).

Belongs to the DNA2/NAM7 helicase family.

122.339 kDa

MSVEAYGPSSQTLTFLDTEETELLGADTQGSEYDFTDFTLPSQTQTQGHTQSQLDNQLNGPDDGLHNGGMDDSVAKASQLLAELNFEEDEEDTYYTKDLPVHACRSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKDNPCATLEDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDSYGDEIAIELRTSVGAPVEIPHNYQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVTIKCQLPKRFTANGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLSRQGNGPVLVCAPSNIAVDQLTEKIDKTGLKVVRLCAKSREAIESPVSFLALHNQISNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVIWCTCVRAGDPRLAKMQFRSILIDESTQATEPKCIGPVELGAKQLILGEITASWSCVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAGDRIKKGFDFQWPQPEKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTRLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRAKYGVIIVGNPKALSKQPLWNNLLNNYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPRFMSTAMYDAREALIPGSAYDRSNTGGRPSNMYFQTHDQIGMIGAAASHLAALNIPIPFNLVMPPMPPPSYQGQTNGPAAGRGAMKGKSGRGGRQRIQWFWEPGGWSHAKQSDQPGWGFPVILSGATDTGLHLHEPAFPDEPARTLPARALPWDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY