Protein
NADPH--cytochrome P450 reductase
Organism
Dictyostelium discoideum
Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Similarity
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Sequence
MEILESIDFIEVLILDNLGAIIIVAVIVGTYLYMNKPPPPPPVFNKPNNKINKEAQKPKKTITKNEDGKKVMKIFFGTQTRTAEDFSRIIEKECKKIGIPCEVVDLESYEHEQELHSESFVMFLVATHGEGDPTDNAKEFYLWLTNDERPTDLLNGVPFTVFGLGNKTYEHYNAVARVIDRRMEELGGKRVFERGEGDDDATLEEDFNRWKKDMWPVVCKFLGYELKSTEDDKFVPRFRMVTLNQDSKDINDPFIKIVSTPLKPKLSTDNKVIYDMKNPYYAEVLENRELHSNESDRSCRHIEFKLGDEVSYTTGDHLGVFPINDSKLVEQLIKRLGVNGDDMIALVPIDQEGSVIKASFGPMTIRRAFSEHLDITNPVRKSVLRALAESTTNEEEKKRLLYLATEEANEEYNKYIKNDFRGVVDLLESFPGLQPLIAHFLEFTPRLPARMYSISSSPHNKNGVVSITSVVVNFTTGNQRAHNGVASTWLSHLKVGDKVPLFVRESHFKLPSAATEQKPVIMVGPGTGLAPFRGFLQELQHRNHSQQQQSLLFFGCRSDTVDYIYREELEQYHQSSVLGDLVVAFSRKTSQKVYVQNKLLEHKEKVWELLNKGAYFYVCGDGRNMSKAVQQALLSIIKEFGSKDDNSAQQFIDDMSSHGRYLQDVWF