Protein
Meiotic recombination protein rec-8
Organism
Caenorhabditis elegans
Function
Plays a role in meiotic chromosome cohesion and segregation (PubMed:11390355, PubMed:25171895). Necessary for sister chromatid co-orientation and sister chromatid cohension until meiosis II (PubMed:19574299). May also be required for repair of programmed meiotic double stranded breaks (PubMed:11390355). During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division (PubMed:23401519).
Similarity
Belongs to the rad21 family. Highly divergent.
Sequence
MVVSAEVIRKDAVFHVAWILGTGDSKKLSRREILDQNLPELCHSIIEMVPERHRGSATKTGLYLLSLLTYGTVLIHQVQVDFLKRDVEKLKELMKKKSFILLMAERFDRNQELQRKEDKFARLRSKPIMCVEELDRVDLAHLQAIGDELGINGNPGDFIMMDALPNMNQWIDNNSELNAIYGCVEPYLREKEITMHSTFVEGNGSNEHNKERRNDAVIADFSQLLFPEIPEITLGEKFPIDVDSRKRSAILQEEQEEALQLPKEASEIVQEEPTKFVSIALLPSETVEQPAPQEPIQEPIQPIIEEPAPQLELPQPELPPQLDAIDLVTIPASQQDMVVEYLQLINDLPDDENSRLPPLPKDLELFEDVILPPPAKKSKVEEEEDALERARRRPSSRPVTPINQTDLTDLHSTVRPEDPSFAIDSQIHDVLPQRKKSKRNLPIIHSDDLEIDEAVQKVLQADYSSLVRKKEDVIAKIPPKTDAVAVLMNLPEPVFSIGYRLPPEVRDMFKACYNQAVGSPVSDDEEDEDEEEEEEYKYAKVCLLSPNRIVEDTLLLEEQPRQPEEFPSTDNINPPRQLQENPVFENLEYEAPPHPIRTARTPTPIKDLKYSVISLFPTPEKRRETSIIAELNLDPIPVEEIDPLLTMRTEEELENVRRRQKSSLGVQFMRTDDLEEDTRRNRLFEDEERTRDAREDELFFYSSGSLLPNNRLNIHKELLNEAEARYPEWVNFNEFTADHDRKKAATAFEGLLLSLKNMKVEAKQEDPYFPILVRHISHEEM