Protein
Demethylrebeccamycin-D-glucose O-methyltransferase
Organism
Lechevalieria aerocolonigenes
Function
Glycosyl O-methyltransferase that catalyzes the final step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid that inhibits topoisomerase 1. Has broad substrate specificity and functions as glycosyl O-methyltransferase on a number of rebeccamycin analogs.
Similarity
Belongs to the methyltransferase superfamily.
Sequence
MTESKSEGTAVAAPTPEEVRQMYDDFTDPFARIWGENLHFGYWEDAGADVSVDDATDRLTDEMIALLDVRSGDRVLDVGCGIGKPAVRLATARDVRVTGISISRPQVNQANARATAAGLANRVTFSYADAMDLPFEDASFDAVWALESLHHMPDRGRALREMARVLRPGGTVAIADFVLLAPVEGAKKEAVDAFRAGGGVLSLGGIDEYESDVRQAELVVTSTVDISAQARPSLVKTAEAFENARSQVEPFMGAEGLDRMIATFRGLAEVPEAGYVLIGARKP