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rebG

Gene
rebG
Protein
4'-demethylrebeccamycin synthase
Organism
Lechevalieria aerocolonigenes
Length
421 amino acids
Function
Catalyzes the penultimate step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid that inhibits topoisomerase 1. Has a wide substrate range, including staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin and indolo-[2,3-a]-carbazole.
Similarity
Belongs to the glycosyltransferase 28 family.
Mass
46.021 kDa
Sequence
MGARVLVATTPGDGHVNPMVPVAQEMVSRGHEVRWYTGKAFRSTVERTGARHEPMRDAHDFGGMPREEAFPQHAGLTGITGMIAGFRDIFIEPAADQMTDLLALLEDFPADVLVTDETFFGAGFVSERTGIPVAWIATSIYVFSSRDTAPLGLGLPPSSSRLGRLRNTVLKQLTDRVVMRDLRRHADVVRDRVGLPRIRKGAFENIMRTPDLYLLGTVPSFEYPRGDMPPEVRFVGPFVSPAPPDFTPPAWWGELDSGRPVVHVTQGTVANDAERLLLPAIRALAAEDVLVVATTGAPLELEPMPANVRVERFIPHHALLPHVDAMVTNGGYGGVNTALAHGVPLVVAAATEEKHEVAARVSWSGAGVHLKKRRLSERDIRRAVRAVLDEPRFRVHAARLRDEYAARDAVVDAVDLIEGLV