Protein
4'-demethylrebeccamycin synthase
Organism
Lechevalieria aerocolonigenes
Function
Catalyzes the penultimate step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid that inhibits topoisomerase 1. Has a wide substrate range, including staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin and indolo-[2,3-a]-carbazole.
Similarity
Belongs to the glycosyltransferase 28 family.
Sequence
MGARVLVATTPGDGHVNPMVPVAQEMVSRGHEVRWYTGKAFRSTVERTGARHEPMRDAHDFGGMPREEAFPQHAGLTGITGMIAGFRDIFIEPAADQMTDLLALLEDFPADVLVTDETFFGAGFVSERTGIPVAWIATSIYVFSSRDTAPLGLGLPPSSSRLGRLRNTVLKQLTDRVVMRDLRRHADVVRDRVGLPRIRKGAFENIMRTPDLYLLGTVPSFEYPRGDMPPEVRFVGPFVSPAPPDFTPPAWWGELDSGRPVVHVTQGTVANDAERLLLPAIRALAAEDVLVVATTGAPLELEPMPANVRVERFIPHHALLPHVDAMVTNGGYGGVNTALAHGVPLVVAAATEEKHEVAARVSWSGAGVHLKKRRLSERDIRRAVRAVLDEPRFRVHAARLRDEYAARDAVVDAVDLIEGLV