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rblA

Gene
rblA
Protein
Retinoblastoma-like protein A
Organism
Dictyostelium discoideum
Length
1312 amino acids
Function
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Plays a dual role, regulating cell-cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, functions in late G2 controlling the expression of both S-phase and mitotic genes. Controls stalk/spore preference by suppressing the DIF response in cells destined for the spore pathway. DIF is a chlorinated hydroxyphenone made by cells of spore pathway that promotes stalk differentiation.
Similarity
Belongs to the retinoblastoma protein (RB) family.
Mass
149.427 kDa
Sequence
MMAHNKNDLTNINTKTTAPTTTTTEQQPEQQQQQPEQQQQEKQNNNNNNNNNNNNNNNINNNENNENNNNDIINNKINLLDELVAAAELKGRYTQIQLEELKSKLDRTSSALNVDQDTIKLAWCLLENMQLVSVDTSEQFQKQIVACSLFICGNKKFSSLLYNLNQPSSSSFQPDNNSKIKGRKIRKTNNSKNKNNDSNEEEEETTTDTEEEEEEDTLLNENNNSINKNSSNNNELLVSIRSCINESGGDSQFLQNSVFLSQLLKHFEGEIKLSQFFDTLRSFISNLRLGNAFEEQGRQLEQSFNTLNNLYRKYEQIFFTLFHPTENYILKTTQQHNYNNNSNNNNNNNNNNNNNNNNNRTNEDYLLSIGWLIFLFCKNKLFTKDSPDFVQSLHLLLCIINFIYVNTSISELKKIPQGVQIIDTATGDILLYLAKSIPCNLDDLSNVNQNIFSTYSNLLINNSILKLFDNNNNNNNNNNNNNNNSDGIKSIFNNSSIIKDNYNSLNKSYELYYYANGDIDERLFYSFDHDIYVLNNNNNNQNNNNNNNNHNNNYYNNNNNNNNNNNNNNHLNYQYSSLLPPSTPTTPSRYGSSSSSGGGGGGNLRKNIYGTPSKSLSAGNLGSVIPQTPISLTLTLESWLKVEIQNYRDPNPSLNLINILKSADQPQQTSEVDKMIERVSSLTNNTDSLFSIGGIDDHQQQQQQQQEVKQRRKNMAIQLYYCLLEKLIKFEQNTSSNINVLLNHEDFHKSLLSNSFEIIAYVYKMEGLYFPHFINVFKLHPFSYLRLIDLVLKVDADLPKLLAQHFSQIEEKILEKYVWSNNSTVFSTIKSHDFQNIFNSNGVGAAITTHLRPTQVFSTPTKNQNNNPFRNQQLINTNIPNTPTKKNPFIQNFIKKVSTLIIAKCRKLIHAMGLSSDYVVQIYQVMIKILIDETLLFKNREIDVLLICSIYAICKVNSKNITFKAIIDKSCISAKVYKEVYIGNDENNNNNNNNNNNNNNNNNNNNNNINNNNNNNENNNNNNNPVKGDIILFYNKIFLTKMDPYIHEVFSKYQQQQQHQYQQPLQNLPPPLLNQNSPKKWNPLFHTPTKNQNNNPYNSNNNTPNKFSSSIPLSPQKGVNYNSSFSVNSMVTISPMKQHTPISSSYTYIVAKSPSKELFQINQCLNKKKNDEMVPPPPTTPSSINNNNNNNNNNNNNNNNNNNNNSNDNNNNNNNNNNNNNNNNSNNNSNNNNNTEKKMVGKRLLFDYEESPSTPSSSSSPTILNNNKKNNNNNKSENVDDPGNNSPSSSPLSSSSSSSSSSSSGGRKRLKS