rasp

Protein-cysteine N-palmitoyltransferase Rasp

500 amino acids

Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling.

Belongs to the membrane-bound acyltransferase family. HHAT subfamily.

58.106 kDa

MSRLPDRSLLTRCEIFVYFGVYIAYIVVGLYKIYGLRDHIVKEAKFQFPEGWSLYPFSQRRRDDSNDELENFGDFIVSFWPFYLLHVAVQGFIRWKRPRLQCLGFIGVCALALSVNLDWSSMVLLVTLIASYYIVSLLSLKFLVWLLSAGWILCINVMQKNVWWTDRVGYTEYVLVIVTMSWSVLRGCSYSLSKIGAKQEDLTRYSLVQYLGYAMYFPCLTYGPIISYQRFAARREDEVQNWLGFVGGVLRSAIWWLVMQCALHYFYIHYMSRDVRMVEMMDSVFWQHSAGYFMGQFFFLYYVVTYGLGIAFAVQDGIPAPNRPRCIGRIHFYSDMWKYFDEGLYEFLFQNIYAELCGKRSSAAAKFGATALTFAFVFVWHGCYTYVLIWSILNFLCLAAEKVFKTFTAMPEYQRWTQRHLGAVGAQRLYAMLATQLFIPAAFSNVYFIGGQEIGDFLMRGAYLSGVGNYVALCFCSYCFFQCSELLLTKSDGRSKTKTF

rasp

Protein-cysteine N-palmitoyltransferase Rasp

500 amino acids

Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling.

Belongs to the membrane-bound acyltransferase family. HHAT subfamily.

58.106 kDa

MSRLPDRSLLTRCEIFVYFGVYIAYIVVGLYKIYGLRDHIVKEAKFQFPEGWSLYPFSQRRRDDSNDELENFGDFIVSFWPFYLLHVAVQGFIRWKRPRLQCLGFIGVCALALSVNLDWSSMVLLVTLIASYYIVSLLSLKFLVWLLSAGWILCINVMQKNVWWTDRVGYTEYVLVIVTMSWSVLRGCSYSLSKIGAKQEDLTRYSLVQYLGYAMYFPCLTYGPIISYQRFAARREDEVQNWLGFVGGVLRSAIWWLVMQCALHYFYIHYMSRDVRMVEMMDSVFWQHSAGYFMGQFFFLYYVVTYGLGIAFAVQDGIPAPNRPRCIGRIHFYSDMWKYFDEGLYEFLFQNIYAELCGKRSSAAAKFGATALTFAFVFVWHGCYTYVLIWSILNFLCLAAEKVFKTFTAMPEYQRWTQRHLGAVGAQRLYAMLATQLFIPAAFSNVYFIGGQEIGDFLMRGAYLSGVGNYVALCFCSYCFFQCSELLLTKSDGRSKTKTF

rasP

Zinc metalloprotease RasP

424 amino acids

Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).

Belongs to the peptidase M50B family.

47.041 kDa

MTTVVAFILMFGVLVSIHEWGHLIFAKRAGMLVREFAIGFGPKIFSFTKNETLYTIRLIPAGGYVRVAGEDPEIIELKPGHHIGLEFNQAGEVSKIIVNNKSKHPYARVIEVENVDLDHKLIIEGYELDDDENRLSFNVNEKAMFVMDERETQIAPYNRQFASKSTGKRAMQLFAGPMMNFVLAIAIFLILGIIQGVPVEEAKLGEIQPDTPAEQAGFQQDDVITQIGDQSISTWEEFTSIVRENPGQELDMVIQRNGESQDISVVPGEAEAVNEVGDPITIGQIGVYQGFEKDVLGTFVYGIERTYDTTTMIIQNLFMLVTGQVSIELLSGPVGIYDATDQVVQTGFSNFLLWTAMLSINLGIINLVPLPALDGGRLLFVGLEAVRGKPIAPEKEGIFHFVGFALLMLLMIVVTWNDIQRLFL

rasP

Regulator of sigma-W protease RasP

422 amino acids

Is responsible for site-2 cleavage of the RsiW anti-sigma factor (PubMed:15130127). This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (PubMed:16899079). Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane (PubMed:21810987).

Belongs to the peptidase M50B family.

46.744 kDa

MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGPKIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQKEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYNRQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEAGLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDENKKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGIYDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINREKEAFVVFIGVAFLMLLMLVVTWNDIQRLFL

rasP

Zinc metalloprotease RasP

421 amino acids

Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).

Belongs to the peptidase M50B family.

46.681 kDa

MVETLESIISFIVVFGALVFFHELGHLLLAKRAGILCREFAIGFGPKVFSFKKNETVYTIRLLPLGGFVRMAGEDPETIELKRGQVVGLLLDESGQVEKIVLNHKDDYPNIRVVEVEEADLEHGMYVTGYTDGERFERFTVKEPAFFVVDRQEIQIAPYHRQFAAKTLGQRTMTILAGPLANFLLSLVVFIIIGLLQGYPVDKPVIGELTPEGAARAAGLKQGDKVIAINGERMETWTEIVNTIRAHPGEPLQFQIERNGKERSVTVTPEAKTVQGETIGLIGVYQPMEKSVLGSIKQGLVETYYWTREIVTGLGQLITGQFQLDMLSGPVGIAVSTGKVAESGIYYLMKWGAILSINLGIVNLLPLPALDGGRLLFFAIEAVRGKPVDRQKEGMVHFIGFALLMLLMLVVTWNDIQKFFL

rasP

Zinc metalloprotease RasP

420 amino acids

Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).

Belongs to the peptidase M50B family.

46.476 kDa

MQTLIAFLVMFGVLVSVHEWGHLYFAKRAGILCREFAIGFGPKLFSWKRNETVYTIRLIPLGGYVRMAGEDPELITIKPGYEVGLVFNEKNVVSRIIVNNKSKHPEAQVVQVERIDLERELFIEAYDDDGERKRWDVDPKAEMVQDEEATQIAPYDRQFGSKSVAQRALAIFAGPLMNFVLAFVLLAAYGFMQGIPVEDPVVGNIAENSAAETAGLQKGDYVLSIDGQTLETWVDMTMIIQQHPNEEITFEVERAGQILQIPVTPNQVEGMDGEPIGLVGIERPAPEPATLVSGLQFGATQTYTYMTMIFDVLRLLVTGQFSLDYVAGPVGIVNYTGQAAEMGIFVLLQWTAALSVNLGIVNLLPLPALDGGRLVFLGLEAVRGKPLDPSKESLVHFVGFALLMLLVLVVTWNDINRLFL

rasP

Zinc metalloprotease RasP

419 amino acids

Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).

Belongs to the peptidase M50B family.

46.45 kDa

MNTVIAFILIFGTLVFFHELGHLILAQRAGILCREFAIGFGPKIFSFKKNETVYTIRLLPIGGFVRMAGEDPEMIEVKPGYTVGLLFDSENKVEKIIINQKEKYPDALVIEVEQADLEHQMRITGYEHGNEDHLSSFSVSETSFFIVDGEEVQIAPYNRQFHSKTVWQRIKAIAAGPIMNFILAYVILVMLGLMQGVPSDEPVLGKLIDNGRAAEAGLQEGDRIQTINGENMRSWTDIVNTVREHPEKELKIVLMRDNVKLTKYVTPEAVKAGDETVGRFGAYNPVKTGVLTSISYGATETATVAQSIVTNLGKLVTGQFSIDMLAGPVGIYDMTDQVAKTGVINLLKLAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINREKEAFVVFIGVAFLMLLMLVVTWNDIQRLFL

rasP

Zinc metalloprotease RasP

418 amino acids

Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).

Belongs to the peptidase M50B family.

46.057 kDa

MNTLLAFIAIFSVLVFVHEWGHLYFAKKAGILCYEFAIGMGPKLFAFERNDTIYTIRLLPIGGYVRMAGEEPEQPTIRPGYEIGLVLDEKDTVKELIVNNKSKHPEAQVVQVERIDLVHDLFVETIDEDTGELVRYPIDEKAFIVQDEVAQIIAPWKRQFGSKPLPKRAMAIFAGPLMNFILGFVILLGLSLYQGVTLSSEIVINGENSPAEAAGLQDGDVITAVNGVEVDSWKEMTTEVKKYPGEEVSIDYERNGEALQTNATLSQVEVMPDEYEGFLGVSGVPEFSLLGSLQYAGNEFINMATSIFDTLGLIFTGQFSLDYISGPVGIYDITDQAVSLGIQTVIFFAALLSINLGVINLMPIPALDGGRLMFLAYEGIRGKPVSPEKEGAIQFIGFALVMLLMIVVTWNDISKLFS