Protein
L-lysine cyclodeaminase
Organism
Streptomyces rapamycinicus (strain ATCC 29253 / DSM 41530 / NRRL 5491 / AYB-994)
Function
Converts L-lysine to L-pipecolate, which is incorporated into multiple secondary metabolite products, including rapamycin, tobulysin, virginiamycin and pristinamycin.
Similarity
Belongs to the ornithine cyclodeaminase/mu-crystallin family.
Sequence
MQTKVLCQRDIKRILSVVGRDVMMDRLISEVHAGFARLGRGETDEPPPRTGFARGGDVPGVIEFMPHRASGIGVTMKTVSYSPQNFERFNLPTIVGTVSRLDDDSGSMVALADAATITAMRTGAVAAVATRLLARPGSTTLALIGAGAQAVTQAHALSRVLPLERILISDIKAEHAESFAGRVAFLELPVEVTDAATAMATADVLCTVTSVPVGGGPVVPAEPRQAHLHVNGIGADEQGKTELPKALLDDAFICVDHPGQARAEGEFQQLPDRELGPSLADLCAAPEIAAPHPERLSVFDSTGSAFADHIALDVLLGFADELGLGHKMSIESTPEDVLDPYSL