Protein
RNA polymerase-associated protein RapA
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.
Similarity
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Sequence
MDMAQYQPGQRWISDSEAELGLGTILAQDGRLLTVLYPATGDTRQYALRNAPLTRVRFAPGDEVTHFEGWKMTVREVEESEGLLVYHGLTAQNEQRTLPETQLSNFIQFRLASDRLFAGQIDPLPWFSLRYHTLERRSQLLQSSLWGLGGARAQPIAHQLHIAREVADRMAPRVLLADEVGLGKTIEAGLIIHRQLLSGRAGRVLILVPENLQHQWLVEMRRRFNLQVALFDKERFAESDASNPFEDTQLALVALEWLKEDERAQDALFAAGWDLLVVDEAHHLVWHQDQVSAEYALVEQLAEIIPGVLLLTATPEQLGQDSHFARLRLLDPNRFHDLEAFRRESEQYRPVAEAVQELLDHGSLSAGARKAIHGFLGSEGDELLASVEGGDEEARSRLVRELLDRHGTGRVLFRNTRAAVQGFPQRELHAYPLPMPSQYEELPAGEHPDLYPEVNFQQQWEDGDDNNRWWRFDPRVEWLIDTLKMLKQFKVLVICAHAETALDLEDALRLRSGISATVFHEGMSILERDRAAAYFADEEFGAQVLICSEIGSEGRNFQFAHHLVLFDLPAHPDLLEQRIGRLDRIGQRHTIQLHVPHLENSAQQRLFQWYHQALNAFLNTCPTGNALQHEFGPRLLPLLDGGEDKAWDALLAEGRARREALEAELHSGRDRLLELNSGGAGEGEALVEAIEEQDDDFALPIYMERLFDAYGIHSEDHSENALILKPSEKMLDAGFPLGDDEGVTITYDRAQALAREDMQFLTWEHPMVQGGMDLVLSGSMGNTSVALIKNKALKPGTVLLELLFVSEAVAPRALQLGRWLPPQALRCLLDANGNDLAGRVSLETLNDQLESVPRVSANKFVQAQRDVLAKQFDVAEGKIVPRHEERVARAKQQFAAAMDEELARLTALKAVNPSVRDSELDSLRTQREEGLALLDKASLRLEAIRILVAG