Function
GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.
Sequence
MLPRLFLTILPVCSPSISNKTSKKFRDAHANHVFLFEMDLNNTLSFFGKQLKLDTEEEISKVIDQIRKHLNLEVLDFRGNTLSVLAGKLIAESLKTRRELKECIWSDMFTGRLKDEIPLVLDALGEALTASGCRLTTLDLSDNAFGAGLSTSLYNFLQSPALYSLENLILNNNGLGLAGKTVGKALCSLIDASKKAGTPLKLKKFVCGRNRLEVESTIALSDAFIKLGTLEEIRLPQNGIRDDGIIALAEAFRMNKKLRIIDINDNFCCPEGAIQISEVLSDLQFIEVLDLGDCVCDDPGVLAIIAELDKINRDCLKKVVLSGNNITSDVIDEIGACFNSPKMCHVKVDISVNMFGKDFDSAKARHGKGNIDFGRRGDDELLSSDEEEEQGAEDASMEEDAFNTSRETVIDRSNLHEASADEMMNDLMNKGFGCMKIEDNQQNSNGNGMVSFLDKSLKLDTAESAEPVVKVIAAASSMKALELRGNTLGIAAGNVIAKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKDLLESPSSFSLEVLKLNNNGLGIGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGAHALAATFKALETVEWFDVRQNGIHEEGIRALVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLESWPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQKWSKFDGLTPKPVLHIHTNSFGDEFSDVAGMAPENVNVGDEDDDLGSLDGDQEEYNSKSSDSEDADLDDDDEDDDEEAEIQIIDNGESQLKLAMDRIDRLDIDFESRFQEDTARVILQLSAPLKSCKMSEPALQRAIEVAENIVRRVESVKRNPIPATTQLVNNIVAQCAGTGVKAETDWGYGADPQVISRLFSELVARGHFKLELALLQRFFPSQ