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rad51d

Gene
rad51d
Protein
Probable DNA repair protein RAD51 homolog 4
Organism
Dictyostelium discoideum
Length
354 amino acids
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Similarity
Belongs to the RecA family. RAD51 subfamily.
Mass
40.822 kDa
Sequence
MEEESISGLEVRFYQTQCLSEDNVIKFENNGYPMIDLILFSDAYQIQRNTSIPIETVTLIQRNLQRLFSSVPINGYQHYLDVKEFKTHYSSGIKLLDQLLGGNGFTSGEIYELVGNTSCGKTQISMCCSLNLSQQYNSNIIYIDSSNSFSPPRLIEIFKSNYLIKQRQKQQQKQQQKQHQKQQENNDKIEQDKILKILDRIKVFNCFDSITLLELLSTIDSTLSIISDEIPTFENQFYKGLKMVVIDSIGTLLAPIIGGKQTQGHYTMMMISRLIKYIADTYQIIFLITNNTVGGNSFDNKAALGEAWSMVPNHQLMINHQYNDDENEERSIYIEKSTRLPVSIIFIINLYWLF

Gene
Rad51d
Protein
DNA repair protein RAD51 homolog 4
Organism
Mus musculus
Length
329 amino acids
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity).
Similarity
Belongs to the RecA family. RAD51 subfamily.
Mass
35.26 kDa
Sequence
MGMLRAGLCPGLTEETVQLLRGRKIKTVADLAAADLEEVAQKCGLSYKALVALRRVLLAQFSAFPLNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCVAANVAHSLQQNVLYVDSNGGMTASRLLQLLQARTQDEEKQASALQRIQVVRSFDIFRMLDMLQDLRGTIAQQEATSSGAVKVVIVDSVTAVVAPLLGGQQREGLALMMQLARELKILARDLGVAVVVTNHLTRDWDGRRFKPALGRSWSFVPSTRILLDVTEGAGTLGSSQRTVCLTKSPRQPTGLQEMIDIGTLGTEEQSPELPGKQT

Gene
RAD51D
Protein
DNA repair protein RAD51 homolog 4
Organism
Homo sapiens
Length
328 amino acids
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
Similarity
Belongs to the RecA family. RAD51 subfamily.
Mass
35.049 kDa
Sequence
MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQFSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARDLGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQSATLQGDQT

Gene
RAD51D
Protein
DNA repair protein RAD51 homolog 4
Organism
Bos taurus
Length
326 amino acids
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity).
Similarity
Belongs to the RecA family. RAD51 subfamily.
Mass
34.651 kDa
Sequence
MGVLRAGLCPGLTQDMVQLLQSRGIKTVVDLVCADLEEVAQKCGLSYKALVALRRVLLAQFSAFPFNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGAPGSGKTQVCLCVAAHVAHGLQQNVLYIDSNGGLTASRILQLLQARTPDEEEQAGALQRIQVVRAFDIFQMLDVLQDLRGAVSQQVSSSSGTLKVVVVDSVAAVVAPLLGGQQREGLALMMQLARELKTLARDLSVAVLVTNHMTRDRDSGQLKPALGRSWSFVPSTRLLLDSTQSSGSLGSWRVVCLTKSPRLPTGCQETVDLGSLGTPAFQGDHKGH

Gene
RAD51D
Protein
DNA repair protein RAD51 homolog 4
Organism
Arabidopsis thaliana
Length
322 amino acids
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Similarity
Belongs to the RecA family. RAD51 subfamily.
Mass
35.384 kDa
Sequence
MAPLKHLEKENPIIDACFQDFCASHGILTIEDFLLHDLYELTAFSQRQTNADRLKEGITLILSLIERQCRPLVNGLKLLEDLHRNKHTLSTGDKETDSLLQGGFREGQLTELVGPSSSGKTQFCMQAAASVAENHLGRVLYLDTGNSFSARRIAQFICSSSDATLGQKVMSRILCHTVYDIYTLFDTLQDLEITLRLQMNVNESRLRLLVVDSISSLITPILGGSGSQGRALMVAIGYLLKKLAHEHSIAILVTNHTVGAGGEGGKTKPALGETWKSIPHVRLSLSRDHKNSNCTISILKHTSLPSGQAAKTLTRKENQQCP