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pym1b

Gene
pym1b
Protein
Partner of Y14 and mago B
Organism
Salmo salar
Length
192 amino acids
Function
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
Similarity
Belongs to the pym family.
Mass
21.26 kDa
Sequence
MATPYVEDESGKYIAATQRPDGTWRKPRKVKDGYTPQEEVPVYENKFVKFFKGKPDLPPGMSPGDEAQARQQQQGIPGIAESETAGLSKTAKRNMKRKEKRKLQGPDSNVEALINAVEMPTSNPAEATNDPSGAAAEKAKKIKNLKKKLRQVEELQQKLDSGEIKQATKEQLDKLGRAKAIQDGLLQLEEDS