Protein
3-methylornithyl-N6-L-lysine dehydrogenase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Function
Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate. Is required for the biosynthesis of pyrrolysine.
Similarity
Belongs to the PylD family.
Sequence
MALLTPEDLENINRQLHEADSTVRRVTGLDIKGVCKDFYGTTPCCEKVGIVPVTSGNGIIGNFSESLRAITEYFGFDSFVTTMPDVSGYYEAVRNGAQIILMADDNTFLAHNLKNGKIANNQPCTGIIYAEIASRYMKADSKDVLAVGLGKVGFPGAAHLVNKGFRVYGYDADKALLEKTVSDLGITPFEPENPRRFSIIFEATPCADTVPESVISDNCVISTPGIPCAISRELQEKYGVELIMEPLGIGTASMLYSIL