ptlE

Gene

ptlE

Protein

Neopentalenolactone D synthase

Organism

Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)

Length

594 amino acids

Function

Catalyzes the flavin-dependent Baeyer-Villiger oxidation of 1-deoxy-11-oxopentalenic acid to neopentalenolactone D in the biosynthesis of neopentalenolactone antibiotic.

Similarity

Belongs to the FAD-binding monooxygenase family.

Mass

65.925 kDa

Sequence

MVDIEAVRAKYREERDKRVQADGGRQYLSAQGEFAHYADDPHAKPIERAPVSDEVDVTIIGAGIGGLLLGARLREACAFDTIRLVDKAGDVGGTWYWNRFPGLRCDVESYVYMPLLEELGRLPSEKYATGAEIFEHCQAIARTYDLYDEALLQTSVTELSWDEDSSRWLVRTDRGDLVRSRFVAMAIGSLHRPKLPSIPGTEAFQGHSFHTSRWDFAYTGGDISGGLEKLGDKRVGIVGTGATAVQCIPHLAESAAHLYVFQRTPSTVSVRNNRPTDPGWAAGLEPGWQQRRMDNFHALTSGVDQDVDLVQDGWTEITSKLAAILPKSAADADPKDIGTAVELADFHKMEELRKRVDAIVHDKDTADALKPYYRLFCKRPCFHDGYLDTYNRPNVTLVDTQGRGVERLTPTSVVAGGREYPVDCLIFASGYESEFGVPYTNRTGFSIVGRDGIRLSEKWAEGARTFHGLQVNGFPNCFILSKAQSGLHVNVPYMLNEQSKHVAYILKAVQQRGRQVVEASATGEKEWVETILRLANRNLDFTESCTPGLFNNEGNPRNVAILNSSYGGGSVGFVNILKRWREADDLADLELREG

Protein

Neopentalenolactone D synthase: ptlE

Gene

ptlE

Protein

Type IV secretion system protein PtlE homolog

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

Length

233 amino acids

Similarity

Belongs to the virB8 family.

Mass

26.022 kDa

Sequence

MPDPRPLTPDQTHGRGHAEAAVDWEASRLYRLAQSERRAWTVAWAALAVTALSLIAIATMLPLKTTIPYLIEVEKSSGAASVVTQFEPRDFTPDTLMNQYWLTRYVAARERYDWHTIQHDYDYVRLLSAPAVRHDYETSYEAPDAPDRKYGAGTTLAVKILSAIDHGKGVGTVRFVRTRRDADGQGAAESSIWVATVAFAYDRPRALTQAQRWLNPLGFAVTSYRVDAEAGQP

Protein

Type IV secretion system protein PtlE homolog: ptlE

Gene

ptlE

Protein

Type IV secretion system protein PtlE homolog

Organism

Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

Length

233 amino acids

Similarity

Belongs to the virB8 family.

Mass

25.994 kDa

Sequence

Protein

Type IV secretion system protein PtlE homolog: ptlE

Gene

ptlE

Protein

Type IV secretion system protein PtlE

Organism

Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

Length

233 amino acids

Function

Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. Could possess peptidoglycanase activity.

Similarity

Belongs to the virB8 family.

Mass

25.994 kDa

Sequence

Protein

Type IV secretion system protein PtlE: ptlE