About Products Protein Database Contact

psmA2

Gene
psmA2
Protein
Proteasome subunit alpha 2
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Length
249 amino acids
Function
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta-alpha2 proteasome is able to cleave oligopeptides after Tyr and thus displays chymotrypsin-like activity.
Similarity
Belongs to the peptidase T1A family.
Mass
26.727 kDa
Sequence
MNRNDKQAYDRGTSLFSPDGRIYQVEYAREAVKRGAPVLGVRTADGVVLAALRSTPSELMEAESIEKLHKLDDALGAATAGHVADARKLVDFARTTAQREHLRYGEPIGVETLTKTITDNIQESTQSGGTRPYGASLLIGGVENGSGRLFATDPSGTPQEWKAVAIGGHREDVQAALEDGYAEDLSLEDGLALAVEALVAADEEIESDELNLVTVSEAGYEIVDEETIAELFADATADDESDETDEREE

Gene
psmA2
Protein
Proteasome subunit alpha 2
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Length
244 amino acids
Function
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Similarity
Belongs to the peptidase T1A family.
Mass
26.786 kDa
Sequence
MQGNEQQAYDRGITIFSPDGRLYQVEYAREAVKRGTASVGVRTEDGVVIAADRHARSPLIERDSIEKIHEIDSHVGVASAGHVADARQLIDVARRQSQVNRLRYDEPASVESLTKEITDYIQQYTQTGGARPFGVALLVAGIEDGEPRLFETDPSGTPYEWQAVAIGGSREDIQTFLEEEYAEGMDLEGGIELALRALASVNEDGLDATGVDIATIDVESEQFEKLAEDDIAERLEEFELGGEE

Gene
PSMA2
Protein
Proteasome subunit alpha type-2
Organism
Bos taurus
Length
234 amino acids
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Similarity
Belongs to the peptidase T1A family.
Mass
25.899 kDa
Sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA

Gene
psma2
Protein
Proteasome subunit alpha type-2
Organism
Carassius auratus
Length
234 amino acids
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation (By similarity).
Similarity
Belongs to the peptidase T1A family.
Mass
25.878 kDa
Sequence
MADRGYSFSLTTFSPSGKLVQIEYALAAVAAGAPSVGIKASNGVVLATEKKQKSILYDEQSVHKIEPITKHIGMVYSGMGPDYRVLVRRARKLAQQYFLVYQEPIPTGQLVQRVASVMQEYTQSGGVRPFGVSLLIAGWDEDRPYLFQSDPSGAYFAWKATAMGKSYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEENIEVGICNEAGFRRLSPAEVKDYLAAIA

Gene
PSMA2
Protein
Proteasome subunit alpha type-2
Organism
Homo sapiens
Length
234 amino acids
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Similarity
Belongs to the peptidase T1A family.
Mass
25.899 kDa
Sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA

Gene
Psma2
Protein
Proteasome subunit alpha type-2
Organism
Mus musculus
Length
234 amino acids
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Similarity
Belongs to the peptidase T1A family.
Mass
25.927 kDa
Sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA

Gene
Psma2
Protein
Proteasome subunit alpha type-2
Organism
Rattus norvegicus
Length
234 amino acids
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Similarity
Belongs to the peptidase T1A family.
Mass
25.927 kDa
Sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA

Gene
psma2
Protein
Proteasome subunit alpha type-2
Organism
Xenopus laevis
Length
234 amino acids
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Similarity
Belongs to the peptidase T1A family.
Mass
25.834 kDa
Sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAAGAPSVGIKATNGVVLATEKKQKSILYDEQSAHKVEPITKHIGMVYSGMGPDYRVLVRRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLIAGWDEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFKRLTPAEVKDYLAAIA

Gene
psmA2
Protein
Proteasome subunit alpha type-2
Organism
Dictyostelium discoideum
Length
232 amino acids
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Similarity
Belongs to the peptidase T1A family.
Mass
25.666 kDa
Sequence
MDSDYSFSLTTFSPSGKLVQIEHALQAAASGGSAIGIKAKNGVVLITEKKLHSLVDVTSVQKISMITENIGLVYAGMGPDSRVLIKKARKESEKYYKQYKEKIPVLQLVRELASIMQEFTQSGGVRPFGVSLLVAGFDEKGPHLYQVDPSGSYFAWKATAIGKNMVSSKTFLEKRYSDDLEIEDAIQTALITIKEGFETQLTEFNMELAIIGKNQEFKILTPAQIKDYLLNL

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain JH1)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain USA300)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection. Stimulates the secretion of the chemotactic factor interleukin-8 (IL-8). The ensuing activation process triggers an inflammatory response in the host, thus contributing greatly to virulence. Also possesses hemolytic activity, which may contribute to the development of disease.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain JH9)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain COL)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain Newman)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain N315)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain MRSA252)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain MSSA476)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK

Gene
psmA2
Protein
Phenol-soluble modulin alpha 2 peptide
Organism
Staphylococcus aureus (strain MW2)
Length
21 amino acids
Function
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection. Stimulates the secretion of the chemotactic factor interleukin-8 (IL-8). The ensuing activation process triggers an inflammatory response in the host, thus contributing greatly to virulence. Also possesses hemolytic activity, which may contribute to the development of disease.
Similarity
Belongs to the phenol-soluble modulin alpha peptides family.
Mass
2.278 kDa
Sequence
MGIIAGIIKFIKGLIEKFTGK